國際期刊（2018年14篇、2019年23篇、2020年23篇、2021年37篇、2022年52篇、2023年37篇；6年共186篇，IF 值＞6，6年共66篇）
備註：Impact Factor>6之高影響力期刊，以黃底標示。
| 年度 | 編號 | 作者(請按順序填寫) | 中心參與人員 | 標題 | 期刊名稱 | ISSN | 發表年 | 卷 | 期 | 頁碼(起) | 頁碼(迄) | DOI 碼 | IF值 | 期刊分類 | |
| 112 | 1 | Mao, Bin-Hsu., Nguyen Thi, Kim Mai., Tang, Ming-Jer., Kamm, Roger D.. Tu, Ting-Yuan. | Tang, Ming-Jer | The interface stiffness and topographic feature dictate interfacial invasiveness of cancer spheroids. | biofabrication | 17585090 | 2023 | 15 | 1 | - | - | 10.1088/1758-5090/acaa00 | 9.954 | Cancer & Others | |
| 112 | 2 | Wang, Shao-Ming., Hsu, Jung-Yu C., Ko, Chiung-Yuan., Wu, Hsiang-En., Hsiao, Yu-Wei., Wang, Ju-Ming. | *Wang, Ju-Ming | Astrocytic Cebpd Regulates Pentraxin 3 Expression to Promote Fibrotic Scar Formation After Spinal Cord Injury. | Molecular Neurobiology | 8937648 | 2023 | - | - | 10.1007/s12035-023-03207-z | 5.59 | Fibrosis & Regenerative Medicine | |||
| 112 | 3 | Ngan Ngo, Thi Kim., Kuo, Cheng-Hsiang., Tu, Ting-Yuan. | Kuo, Cheng-Hsiang Tu, Ting-Yuan |
Recent advances in microfluidic-based cancer immunotherapy-on-a-chip strategies. | Biomicrofluidics | 19321058 | 2023 | 17 | 1 | - | - | 10.1063/5.0108792 | 3.258 | Cancer & Others | |
| 112 | 4 | Cheng, Yu-Sheng., Chen, Hsing-Yi., Lin, Yu-Chiao., Lin, Yi-Syuan., Yeh, Yi-Chun.,.Yeh, Yi-Hsuan., Cheng, Yung-Hsuan., Lin, Yung-Ming., Weng, Han-Yu., Lin, Tsung-Yen., Lin, Shih-Chieh. | Yeh, Yi-Chun | The MAEL expression in mitochondria of human spermatozoa and the association with asthenozoospermia | Andrology | 20472919 | 2023 | - | - | - | - | 10.1111/andr.13408 | 4.456 | Cancer & Others | |
| 112 | 5 | Chu, Dinh-Toi., Ngo, Anh-Daoa., Wu, Chia-Ching. | Wu, Chia-Ching | Epigenetics in cancer development, diagnosis and therapy | Progress in Molecular Biology and Translational Science | 18771173 | 2023 | - | - | - | - | 10.1016/bs.pmbts.2023.01.009 | Cancer & Others | ||
| 112 | 6 | Chen, Chi-Hsuan., Hsu, Chao-Kai., Lee, Chaw-Ning. |
Hsu, Chao-Kai. | Tepotinib-Induced Palmoplantar Keratoderma-Like Hand-Foot Skin Reaction | Journal of Thoracic Oncology | 15560864 | 2023 | 18 | 4 | 33 | 34 | 10.1016/j.jtho.2022.11.020 | 20.121 | Cancer & Others | |
| 112 | 7 | Kuo, Ho-Chang., Kuo, Kuang-Che., Du, Pin-Xian., Keskin, Batuhan Birol., Su, Wen-Yu., Ho, Tzong-Shiann., Tsai, Pei-Shan., Pau, Chi Ho., Shih, Hsi-Chang., Huang, Ying-Hsien., Weng, Ken-Pen., Syu, Guan-Da. | *Syu, Guan-Da | Profiling Humoral Immunity After Mixing and Matching COVID-19 Vaccines Using SARS-CoV-2 Variant Protein Microarrays | Molecular and Cellular Proteomics | 15359476 | 2023 | 22 | 4 | - | - | 10.1016/j.mcpro.2023.100507 | 7.381 | Biomaterials & Stem Cells | |
| 112 | 8 | Huang, Christina Bao Xian., Tu, Ting-Yuan. | *Tu, Ting-Yuan | Recent advances in vascularized tumor-on-a-chip | Frontiers in Oncology | 2234943X | 2023 | 13 | - | - | - | 10.3389/fonc.2023.1150332 | 5.738 | Cancer & Others | |
| 112 | 9 | Lin, Yu-Chen., Jeng, Yu-Chen., Aala, Wilson Jr F., Hong, Yi-Kai., Chen, Pin-Hsuan., Chuang, Ya-Ru., Yang, Chao-Chun., Hsu, Chao-Kai | *Lin, Yu-Chen Hong, Yi-Kai Yang, Chao-Chun *Hsu, Chao-Kai |
Transcriptomic responses of peripheral blood mononuclear cells to cyclosporin and etanercept in a female infant with juvenile generalized pustular psoriasis | Experimental Dermatology | 9066705 | 2023 | - | - | - | - | 10.1111/exd.14835 | 4.511 | EB & genetic diseases | |
| 112 | 10 | Huang, Hsin-Yu., Wu, Cheng-Ju., Lee, Julia Yu-Yun., Liao, Yi-Chen., Hsu, Chao-Kai. | Lee, Julia Yu-Yun Hsu, Chao-Kai |
Lymphocytic thrombophilic arteritis following mRNA-1273 severe acute respiratory syndrome coronavirus 2 vaccination: A case report and review of the literature | Dermatologica Sinica | 10278117 | 2023 | 41 | 1 | 44 | 45 | 10.4103/ds.DS-D-22-00031 | 1.107 | Neurovascular Regenerative Medicine | |
| 112 | 11 | Liu, Wei-Ting., Yang, Chao-Chun. | *Yang, Chao-Chun | Myositis-specific antibodies in dermatomyositis: A single-center experience of 33 cases in Taiwan | Dermatologica Sinica | 10278117 | 2023 | 41 | 1 | 31 | 35 | 10.4103/ds.DS-D-22-00122 | 1.107 | Cancer & Others | |
| 112 | 12 | Jeng, Yu-Chen., Lin, Yu-Chen., Hsu, Chao-Kai., Lee, Julia Yu-Yun., Lee, Chaw-Ning. | Lin, Yu-Chen Hsu, Chao-Kai |
Generalized pustular psoriasis caused by bupropion with rapid recurrence after self-rechallenge | Experimental Dermatology | 9066705 | 2023 | - | - | 1 | 2 | 10.1111/exd.14838 | 4.511 | Hair Follicle & Skin Appendages | |
| 112 | 13 | De Leon, Marco P., Wen, Fu-Lai., Paylaga, Giovanni J., Wang, Ying-Ting., Roan, Hsiao-Yuh., Wang, Chung-Han., Hsiao, Chung-Der., Lin, Keng-Hui | Wen, Fu-Lai | Mechanical waves identify the amputation position during wound healing in the amputated zebrafish tailfin | Nature Physics | 17452473 | 2023 | - | - | - | - | 10.1038/s41567-023-02103-6 | 19.684 | Wound Healing & Plastic Surgery | |
| 112 | 14 | Hsu, Ming-Wei., Chen, Szu-Han., Tseng, Wan-Ling., Hung, Kuo-Shu., Chung, Tzu-Chun., Lin, Sheng-Che., Koo, Jahyun., *Hsueh, Yuan-Yu. | Chen, Szu-Han *Hsueh, Yuan-Yu |
Physical processing for decellularized nerve xenograft in peripheral nerve regeneration | Frontiers in Bioengineering and Biotechnology | 22964185 | 2023 | 11 | - | - | - | 10.3389/fbioe.2023.1217067 | 6.064 | Neurovascular Regenerative Medicine | |
| 112 | 15 | Hou, Ping-Chen., Del Agua, Nathalie., Lwin, Su M., Hsu, Chao-Kai., McGrath, John A. | Del Agua, Nathalie *Hsu, Chao-Kai *McGrath, John A. |
Innovations in the Treatment of Dystrophic Epidermolysis Bullosa (DEB): Current Landscape and Prospects | Therapeutics and Clinical Risk Management | 11766336 | 2023 | 19 | - | 455 | 473 | 10.2147/TCRM.S386923 | 2.9 | EB & genetic diseases | |
| 112 | 16 | Pan, Shin-Chen., Lai, Chi-Hung., Vu, Van-Truc., Vu, Cao-An., Huang, Chun-Jen., Cheng, Chao-Min., Chen, Wen-Yih. | *Pan, Shin-Chen | Paper-Based Exosomal MicroRNA-21 Detection for Wound Monitoring: A Proof of Concept and Clinical Validation Trial Study | International Journal of Molecular Sciences | 16616596 | 2023 | 24 | 12 | - | - | 10.3390/ijms24129822 | 6.208 | Wound Healing & Plastic Surgery | |
| 112 | 17 | Yeh, Jwu-Lai., Kuo, Cheng-Hsiang., Shih, Po-Wen., Hsu, Jong-Hau., I-Chen, Peng., Huang, Yi-Hsun. | Kuo, Cheng-Hsiang | Xanthine derivative KMUP-1 ameliorates retinopathy | Biomedicine and Pharmacotherapy | 7533322 | 2023 | - | 165 | - | - | 10.1016/j.biopha.2023.115109 | 7.419 | Neurovascular Regenerative Medicine | |
| 112 | 18 | Chen, Szu-Han., Wu, Chia-Ching., Tseng, Wan-Ling., Lu, Fu-I., Liu, Ya-Hsin., Lin, Shau-Ping., Lin, Sheng-Che., Hsueh, Yuan-Yu | *Chen, Szu-Han Wu, Chia-Ching *Hsueh, Yuan-Yu |
Adipose-derived stem cells modulate neuroinflammation and improve functional recovery in chronic constriction injury of the rat sciatic nerve | Frontiers in Neuroscience | 16624548 | 2023 | 17 | - | - | - | 10.3389/fnins.2023.1172740 | 5.152 | Neurovascular Regenerative Medicine | |
| 112 | 19 | Hsu, Chao-Kai | *Hsu, Chao-Kai | Scoring systems for pemphigus | Dermatologica Sinica | 10278117 | 2023 | 41 | 2 | 65 | 66 | 10.4103//DS.V41-1_Editorial | 1.107 | EB & genetic diseases | |
| 112 | 20 | Huang, Shang-En., Kuo, Cheng-Hsiang., Shiao, Si-Yu., Shen, Chia-Rui., Lee, Fang-Tzu., Chang, Bi-Ing., Hsu, Jong-Hau., Wu, Hua-Lin., Yeh, Jwu-Lai., Lai, Chao-Han | Kuo, Cheng-Hsiang Wu, Hua-Lin |
Soluble CD93 lectin-like domain sequesters HMGB1 to ameliorate inflammatory diseases | Theranostics | 18387640 | 2023 | 13 | 12 | 4059 | 4078 | 10.7150/thno.84935 | 11.556 | Cancer & Others | |
| 112 | 21 | Cruz, Criselda Jean G., Yang, Chao-Chun | *Cruz, Criselda Jean G. *Yang, Chao-Chun |
Clinical application of serum biomarkers for detecting and monitoring of chronic plaque psoriasis | Frontiers in Molecular Biosciences | 2296889X | 2023 | 10 | - | - | - | 10.3389/fmolb.2023.1196323 | 6.113 | Hair Follicle & Skin Appendages | |
| 112 | 22 | Huang, Shu-Wei., Wu, Yu-Feng., Ahmed, Tanvir., Pan, Shin-Chen., Cheng, Chao-Min | * Pan, Shin-Chen | Point-of-care detection devices for wound care and monitoring | Trends in Biotechnology | 1677799 | 2023 | - | - | - | - | 10.1016/j.tibtech.2023.07.001 | 17.3 | Wound Healing & Plastic Surgery | |
| 112 | 23 | Chiang, Hsueh-Chien., Hughes, Michael., Chang, Wei-Lun | Hughes, Michael | The role of microbiota in esophageal squamous cell carcinoma: A review of the literature | Thoracic Cancer | 17597706 | 2023 | - | - | - | - | 10.1111/1759-7714.15096 | 2.9 | Cancer & Others | |
| 112 | 24 | Keskin, Batuhan Birol., Liu, Shih-Feng., Du, Pin-Xian., Tsai, Pei-Shan., Ho, Tzong-Shiann., Su, Wen-Yu., Lin, Pei-Chun., Shih, Hsi-Chang., Weng, Ken-Pen., Yang, Kuender D., Huang, Ying-Hsien., Kuo, Kuang-Che., Syu, Guan-Da., Kuo, Ho-Chang. | *Syu, Guan-Da | Profiling humoral responses to COVID-19 immunization in Kawasaki disease using SARS-CoV-2 variant protein microarrays | Analyst | 32654 | 2023 | - | - | - | - | 10.1039/d3an00802a | 5.227 | Cancer & Others | |
| 112 | 25 | Cruz, Criselda Jean G., Hong, Yi-Kai., Aala, Wilson Jr. F., Tsai, Ren-Yeu., Chung, Pei-Lun., Tsai, Yau-Sheng., Hsu, Chao-Kai., Yang, Chao-Chun | *Cruz, Criselda Jean G. Hsu, Chao-Kai *Yang, Chao-Chun |
Adipose transcriptome in the scalp of androgenetic alopecia | Frontiers in Medicine | 2296858X | 2023 | 23 | - | - | - | 10.3389/fmed.2023.1195656 | 5.058 | Hair Follicle & Skin Appendages | |
| 112 | 26 | Su, Wen-Yu., Ho, Tzong-Shiann., Tsai, Tien-Chun., Du, Pin-Xian., Tsai, Pei-Shan., Keskin, Batuhan Birol., Shizen, Maulida Azizza., Lin, Pei-Chun., Lin, Wei-Hsun., Shih, Hsi-Chang., Syu, Guan-Da | *Syu, Guan-Da | Developing magnetic barcode bead fluorescence assay for high throughput analyzing humoral responses against multiple SARS-CoV-2 variants | Biosensors and Bioelectronics | 9565663 | 2023 | 241 | - | - | - | 10.1016/j.bios.2023.115709 | 12.54 | Cancer & Others | |
| 112 | 27 | Chiang, Liang-Jui., Shieh, Shyh-Jou | *Shieh, Shyh-Jou | Propeller posterior tibial artery perforator flap for reconstruction of the medial malleolar defect: A case report | Formosan Journal of Surgery | 1682606X | 2023 | 56 | 5 | - | - | 10.1097/FS9.0000000000000068 | 0.4 | Wound Healing & Plastic Surgery | |
| 112 | 28 | Chang, Heng-Ai., Ou Yang, Rui-Zhi., Su, Jing-Ming., Nguyen, Thi My Hang., Sung, Junne-Ming., Tang, Ming-Jer., Chiu, Wen-Tai. | Tang, Ming-Jer | YAP nuclear translocation induced by HIF-1α prevents DNA damage under hypoxic conditions | Cell Death Discovery | 20587716 | 2023 | 9 | 1 | - | - | 10.1038/s41420-023-01687-5 | 7.113 | Fibrosis & Regenerative Medicine | |
| 112 | 29 | Tsai, Pei-Shan., Du, Pin-Xian., Keskin, Batuhan Birol., Lee, Nan-Yao., Wan, Shu-Wen., Lin, Ya-Lan., Su, Wen-Yu., Lin, Pei-Chun., Lin, Wei-Hsun., Shih, Hsi-Chang., Ho, Tzong-Shiann., Syu, Guan-Da | *Syu, Guan-Da | Antibody Profiling of Dengue Severities Using Flavivirus Protein Microarrays | Analytical Chemistry | 32700 | 2023 | - | - | - | - | 10.1021/acs.analchem.3c02165 | 8.008 | Cancer & Others | |
| 112 | 30 | Chen, Chian-Wei., Chang, Chun-Ping., Wen, Yi-Shuan., Kuo, Cheng-Hsiang., Lin, Shang-Wen., Tsai, Jui-Chen., Shyong, Yan-Jye | Kuo, Cheng-Hsiang | Pulmonary delivery of remdesivir and dexamethasone encapsulated nanostructured lipid carriers for enhanced inflammatory suppression in lung | Journal of Drug Delivery Science and Technology | 17732247 | 2023 | 90 | - | - | - | 10.1016/j.jddst.2023.105144 | 5 | Cancer & Others | |
| 112 | 31 | Lin, Wei-Hsun., Du, Pin-Xian., Tsai, Pei-Shan., Keskin, Batuhan Birol., Su, Wen-Yu., Lee, Nan-Yao., Ko, Wen-Chien., Lin, Pei-Chun., Shih, Hsi-Chang., Weng, Meng-Yu., Syu, Guan-Da | *Syu, Guan-Da | Rituximab, but not other biologics, impairs humoral immunity in patients with rheumatoid arthritis - a study using CoVariant protein arrays | Rheumatology Advances in Practice | 25141775 | 2023 | 7 | 3 | - | - | 10.1093/rap/rkad085 | 3.1 | Cancer & Others | |
| 112 | 32 | Pang, Hao-Han., Li, Nan-Si., Hsu, Ying-Pei., Ju, Shin-Pon., Syu, Guan-Da., Du, Pin-Xian., Huang, Chiung-Yin., Wei, Kuo-Chen., Yang, Hung-Wei | Syu, Guan-Da | AI-Driven Design System for Fabrication of Inhalable Nanocatchers for Virus Capture and Neutralization | Advanced Healthcare Materials | 21922640 | 2023 | - | - | - | - | 10.1002/adhm.202302927 | 11.092 | Cancer & Others | |
| 112 | 33 | Francisco, Abialbon G., Reyes, John Carlo B., Tabios, Ian Kim B., Cruz, Criselda Jean G., Ang, Mark Angelo C., Heralde, Francisco M., Lacuna, Azita Racquel G., de Paz-Silava, Sheriah Laine M a |
Cruz, Criselda Jean G | Seroprevalence of human adenovirus type 5 neutralizing antibodies in the Philippines | PloS one | 19326203 | 2023 | 18 | 12 | - | - | 10.1371/journal.pone.0293046 | 3.752 | Cancer & Others | |
| 112 | 34 | Benedet, Patricia O., Safikhan, Nooshin S., Pereira, Maria J., Lum, Bryan M., Botezelli, José Diego., Kuo, Cheng-Hsiang., Wu, Hua-Lin., Craddock, Barbara P., Miller, W. Todd., Eriksson, Jan W., Yue, Jessica T.Y., Conway, Edward M |
Kuo, Cheng-Hsiang | CD248 promotes insulin resistance by binding to the insulin receptor and dampening its insulin-induced autophosphorylation | eBioMedicine | 23523964 | 2023 | 19 | - | - | - | 10.1016/j.ebiom.2023.104906 | 11·1 | Cancer & Others | |
| 112 | 35 | Hsieh, Chu-Han., Lee, Ju., Sung, Hsiang-Hsuan., Huang, Ya-Fang., Ding, Yu-Sian., Li, Chia-Yi., Yen, Chia-Liang., Hsu, Chao-Kai., Yu, Chun-Keung., Hsieh, Hsin-Ying., Hughes, Michael Warren., Chen, Peng-Chieh., Shieh, Chi-Chang |
Hsu, Chao-Kai. Hughes, Michael Warren |
Novel SLC5A6 mutations lead to B lymphocyte maturation defects with metabolic abnormality rescuable by biotin replenishment | Clinical Immunology | 15216616 | 2023 | 257 | - | - | - | 10.1016/j.clim.2023.109855 | 10.1 | EB & genetic diseases | |
| 112 | 36 | Yang, Jia-Yu., Kumar, Amit., Shaikh, Muhammad Omar., Huang, Shu-Hung., Chou, Ying-Nien., Yang, Chao-Chun., Hsu, Chao-Kai., Kuo, Li-Chieh., Chuang, Cheng-Hsin | Yang, Chao-Chun Hsu, Chao-Kai. |
Biocompatible, Antibacterial, and Stable Deep Eutectic Solvent-Based Ionic Gel Multimodal Sensors for Healthcare Applications | ACS Applied Materials and Interfaces. | 19448244 | 2023 | - | - | - | - | 10.1021/acsami.3c09613 | 10.383 | Biomaterials & Stem Cells | |
| 112 | 37 | Yu-Shan Lin., Wen-Hou Huang., Keng-Fu Hsu., Ming-Jer Tang., Wen-Tai Chiu | Ming-Jer Tang | Reversion of chemoresistance by endocannabinoid-induced ER stress and autophagy activation in ovarian cancer | Am J Cancer Res | 2156-6976 | 2023 | 13 | 9 | 4163 | 4178 | PMID: 37818056 | 6.166 | Cancer & Others |
國際期刊（2018年14篇、2019年23篇、2020年23篇、2021年37篇、2022年52篇；5年共149篇，IF 值＞6，5年共49篇）
備註：Impact Factor>6之高影響力期刊，以黃底標示。
2022年國際期刊論文(共52篇，IF 值＞6之高影響力期刊15篇)
1. Hsu CH, Tu WT, Chen PC, Yu-Yun Lee J, Hsu CK, Chiu TM. Novel compound heterozygous ITGB4 mutations underlie lethal junctional epidermolysis bullosa with pyloric atresia and aplasia cutis congenita. Journal of Dermatology.
2022 Jan. (Impact Factor 4.563)
[EB & genetic diseases；新型複合雜合ITGB4突變是致死性大皰性交界性表皮鬆解伴幽門閉鎖和先天性皮膚發育不全的基礎]
2. Kuo TY, Huang CC, Shieh SJ, Wang YB,Lin MJ, Wu MC, Huang Lynn L. H. Skin wound healing assessment via an optimized wound array model in miniature pigs. Scientific Reports, 2022 Dec; 12(1), art. no. 445.
(Impact Factor 4.13)
[Wound Healing & Regenerative Medicine；通過優化的微型豬傷口陣列模型評估皮膚傷口癒合]
DOI:10.1038/s41598-021-03855-y
3. Hou PC, W Aala Jr, Lee YR, B E K Guevara,Chen PC, J A McGrath, Hsu CK. Transcriptomic response of peripheral blood mononuclear cells to secukinumab in an 8-year-old boy with juvenile generalized pustular psoriasis. J Eur
Acad Dermatol Venereol. 2022 Jan. (Impact Factor 2.57)
[EB & genetic diseases；與菲律賓南部醫療中心及英國倫敦國王大學合作一名 8 歲幼年全身膿皰型銀屑病男孩外周血單個核細胞對蘇金單抗的轉錄組學反應]
4. Ho TS, Du PX, Su WY, Harvey M. Santos,Lin YL, Chou YY, Batuhan Birol Keskin, Pau CH, Syu GD. Development of SARS-CoV-2 variant protein microarray for profiling humoral immunity in vaccinated subjects. Biosensors and
Bioelectronics. 2022 Feb Volume 204. (Impact Factor 12.54)
[Biomaterials & Stem Cells；與菲律賓瑪布亞科技學院合作，開發 SARS-CoV-2 變異蛋白微陣列，用於分析疫苗接種對象的免疫反應]
DOI:10.1016/j.bios.2022.114067
5. Hsiao YW, Chi JY, Li CF,Chen LY, Chen YT, Liang HY,Lo YC, Hong JY,Chuu CP,Hung LY, Du JY, Chang WC, Wang JM. Disruption of the pentraxin 3/CD44 interaction as an efficient therapy for triple-negative breast cancers.
Clinical and Translational Medicine. 2022 Jan;12(1):e724. (Impact Factor 11.492)
[Cancer & Others；破壞 PTX3/CD44 相互作用作為三陰性乳腺癌的有效療法]
6. Su CY*, Michael W. Hughes*, Liu TY, Chuong CM, Wang HV*, Wei-Cheng Yang*. Defining Wound Healing Progression in Cetacean Skin: Characteristics of Full-Thickness Wound Healing in Fraser's Dolphins.
(Lagenodelphis hosei) Animals. 2022, 12(5), 537. (Impact Factor 2.752)
[Wound Healing & Regenerative Medicine；鯨類皮膚的傷口癒合進展：海豚 (Lagenodelphishoei)的全層傷口癒合特徵]
7. Tsai WY, Hsueh YY , Chen PY, Hung KS, Huang CC. High-Frequency Ultrasound Elastography for Assessing Elastic Properties of Skin and Scars. IEEE Transactions on Ultrasonics, Ferroelectrics, and
Frequency Control. 2022 Feb 24. (Impact Factor 3.46)
[Wound Healing & Regenerative Medicine；利用超高頻超音波來評估皮膚疤痕的物理性特徵]
DOI:10.1109/TUFFC.2022.3154235
8. Chen H, Hsieh FN, Yang CC. Mucocutaneous hyperpigmentation as a clue to diagnose Addison disease – Two case reports. Dermatol Sin.2022 40(1), 48-49. (Impact factor 1.321)
[Cancer & Others；皮膚的色素變化可以作為診斷腎上腺功能低下的依據]
9. Huang CY, Huang CY, Yang CC, Lee TM, Chang JS. Hair growth-promoting effects of Sargassum glaucescens oligosaccharides extracts. Journal of the Taiwan Institute of Chemical Engineers, 134, art. no.104307.
(Impact Factor 5.76)
[Hair Follicle & Skin Appendages；低分子量的馬尾藻褐藻糖膠提取物促進毛髮生長的活性]
DOI:10.1016/j.carbpol.2021.118811
10. Liang YC, Liu WT, Wu CL, Lee JYY, Yang CC, A case of bullous pemphigoid associated with plasma cell leukemia. Dermatologica Sinica, 2022 40(1), pp. 58-59. (Impact Factor 1.321)
[Cancer & Others；漿細胞白血病伴大皰性類天皰瘡一例 ]
11. Yang MC, Lin YC, Huang CH, Ko TM, Tsai MC, Kuo PL, Lee JYY, McGrath, J.A., Hsu CK. Incontinentia pigmenti in a male infant and a proposed diagnostic algorithm. Clinical and Experimental Dermatology. 2022 Mar.
(Impact Factor 3.47 )
[EB & genetic diseases；男性嬰兒色素失禁和建議的診斷算法 ]
12. Huang HP, Hsu CK, Lee JYY. Topical ivermectin-induced transient flare of rosacea as a host reaction to killed Demodex mites preventable by short-term use of topical corticosteroid. Dermatologic Therapy. 2022 Apr 14;e15517.
(Impact Factor 2.851 )
[Hair Follicle & Skin Appendages；局部ivermectin誘導的紅斑痤瘡短暫發作是宿主對殺死蠕形蟎的反應，可通過短期使用局部皮質類固醇來預防]
13. Lin YC, Tu WT, Hou PC, Huang HY, Chen PC, Chang CH, Lee JYY, McGrath John A., Hsu CK. Autosomal dominant epidermolysis bullosa simplex exacerbated by hyperkeratotic scabies. Journal of Dermatology. 2022 May.
(Impact Factor 4.005 )[EB & genetic diseases；角化過度疥瘡加重的常染色體顯性大皰性表皮鬆解症]
14. Ken Natsuga, Yoshikazu Furuta, Shota Takashima, Takuma Nohara, Huang HY, Satoru Shinkuma, Hideki Nakamura, Yousuke Katsuda, Hideaki Higashi, Hsu CK, Satoshi Fukushima, Hideyuki Ujiie. Cas9-guided haplotyping
of three truncation variants in autosomal recessive disease. Human Mutation. 2022 April. (Impact Factor 4.878 )
[EB & genetic diseases；Cas9 引導的常染色體隱性遺傳病中三種截斷變體的單倍型分析]
15. Hou PC, Huang HY,Lee JYY, Hsu CK. Pyostomatitis vegetans following coronavirus disease 2019 vaccination in a patient with ulcerative colitis. Journal of Dermatology. 2022 May. (Impact Factor 4.005 )
[Mechanobiology & Skin Disease；潰瘍性結腸炎患者接種 2019 年冠狀病毒病疫苗後的增殖性化膿性口炎]
16. Wu LY, Han CL, Lin HH, Tang MJ. Ha-RasV12-Induced Multilayer Cellular Aggregates Is Mediated by Rac1 Activation Rather Than YAP Activation. Biomedicines. 2022, 10(5), 977. (Impact Factor 5.612 )
[Fibrosis & Regenerative Medicine；Ha-Ras V12 - 誘導的多層細胞聚集體由 Rac1 激活而不是 YAP 激活介導]
DOI:10.3390/biomedicines10050977
17. Hsu CK, Cheng NY, Yang CC, Yen YY, Tsen SH. Investigating the clinical implication of corneometer and mexameter readings towards objective, efficient evaluation of psoriasis vulgaris severity. Scientific Reports.
2022 May 6;12(1):7469. (Impact Factor 4.379 )
[Mechanobiology & Skin Disease；調查角膜測量儀和測量儀讀數對客觀、有效評估尋常型銀屑病嚴重程度的臨床意義]
DOI:10.1038 / s41598-022-11573-2
18. Tsai WY, Hsueh YY, Chen PY, Hung KS, Huang CC. High-Frequency Ultrasound Elastography for Assessing Elastic Properties of Skin and Scars. IEEE Trans Ultrason Ferroelectr Freq Control. 2022 Jun;69(6):1871-1880
(Impact Factor 2.725 )
[Mechanobiology & Skin Disease；探討利用超高頻超音波來測量皮膚異常疤痕的彈性以及結構分析]
DOI:10.1109/TUFFC.2022.3154235
19. Chi WY, Hsiao TH, Lee GH, Su IH, Chen BH, Tang MJ, Fu TF. The cooperative interplay among inflammation, necroptosis and YAP pathway contributes to the folate deficiency-induced liver cells enlargement.
Cellular and Molecular Life Sciences, 2022 August 79(8), art. no. 397. (Impact Factor 9.261)
[Mechanobiology & Skin Disease；炎症、壞死性凋亡和 YAP 通路之間的協同相互作用有助於葉酸缺乏誘導的肝細胞增大]
DOI:10.1007/s00018-022-04425-9
20. Liu GY, Chen SC, Lee GH, Kritika Shaiv, Chen PY, Cheng H., Hong SR, Yang WT, Huang SH, Chang YC, Wang HC, Kao CL, Sun PC, Chao MH, Lee YY, Tang MJ, Lin YC.
Precise control of microtubule disassembly in living cells. The EMBO Journal. (2022)e110472.
(Impact Factor 11.598)
[Fibrosis & Regenerative Medicine；精確控制活細胞中的微管分解]
21. Pan SC, Wu YF, Lin YC, Lin SW, Cheng CM, Paper-Based Interleukin-6 Test Strip for Early Detection of Wound Infection. Biomedicines. 2022, 10(7), 1585. (Impact Factor 5.612)
[Wound Healing & Plastic Surgery；用於早期檢測傷口感染的紙質白細胞介素 6 試紙]
DOI:10.3390/biomedicines10071585
22. Yang AM, Lin CY, Liu SH, Syu GD, Sun HJ, Lee, KC, Lin, HC, Hou, MC. Saccharomyces Boulardii Ameliorates Non-alcoholic Steatohepatitis in Mice Induced by a Methionine-Choline-Deficient Diet Through Gut-Liver Axis.
Front. Microbiol., 23 June 2022. (Impact Factor 5.64)
[Fibrosis & Regenerative Medicine；Saccharomyces Boulardii 通過腸肝軸改善由蛋氨酸 - 膽鹼缺乏飲食誘導的小鼠的非酒精性脂肪性肝炎。]
23. Pierre-Alain Burnouf, Steve R.Roffler, Wu CC, Su YC. Glucuronides: From biological waste to bio-nanomedical applications. Journal of Controlled Release. Volume 349, September 2022, Pages 765-782. (Impact Factor 9.776)
[Cancer & Others；葡糖苷酸：從生物廢物到生物納米醫學應用]
DOI:10.1016/j.jconrel.2022.07.031
24. Ho CL, Huang LLH, Shieh SJ. Perichondrial progenitor cells promote proliferation and chondrogenesis of mature chondrocytes. Regenerative Biomaterials. Volume 9, January 2022, rbab078. (Impact Factor 6.353)
[Biomaterials & Stem Cells；軟骨膜祖細胞促進成熟軟骨細胞的增殖和軟骨形成]
25. Kuo CH*, Zhang BH, Huang SE, Hsu JH, Wang YH, Nguyen TTN, Lai CH, Yeh JL. Xanthine Derivative KMUP-1 Attenuates Experimental Periodontitis by Reducing Osteoclast Differentiation and Inflammation.
Front. Pharmacol. 2022 Apr;13:821492. eCollection 2022. (Impact factor 5.988)
[Cancer & Others: 黃嘌呤衍生物應用於牙周炎之治療]
DOI:10.3389/fphar.2022.821492.
26. Yadav, Anjalia*, Ramasamy, Thamil Selvee, Lin SC, Chen, SH, Lu Jean, Liu YH, Lu FI, Hsueh YY, Lin SP, Wu CC*. Autologous Platelet-Rich Growth Factor Reduces M1 Macrophages and Modulates Inflammatory
Microenvironments to Promote Sciatic Nerve Regeneration. Biomedicines. 2022, 10(8), 1991 (Impa ct factor 5.612)
[Wound Healing & Plastic Surgery；自體富含血小板的生長因子減少 M1 巨噬細胞並調節炎症微環境以促進坐骨神經再生]
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27. Chang WT, Lin YW, Chen CY, Chen ZC, Shih JY, Wu CC, Luo CY, Liu PY. Mineralocorticoid Receptor Antagonists Mitigate Mitral Regurgitation-Induced Myocardial Dysfunction. Cells 2022, 11(17), 2750.
(Impa ct factor 7.666)
[Fibrosis & Regenerative Medicine；鹽皮質激素受體拮抗劑減輕二尖瓣關閉不全誘導的心肌功能障礙]
28. Maeng, WY, Tseng WL, Li S, Koo J, Hsueh YY. Electroceuticals for peripheral nerve regeneration. Biofabrication. 2022 Sep 8;14(4). (Impa ct factor 9.954)
[Wound Healing & Plastic Surgery；用於周圍神經再生的電藥] SSCI
29. Harn HI, Chiu PY, Lin CH, Chen HY, Lai YC, Yang FS, Wu CC, Tang MJ, Chuong CM, Hughes MW. Topological distribution of wound stiffness modulates wound induced hair follicle neogenesis.
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[Hair Follicle & Skin Appendages；傷口硬度的拓撲分佈調節傷口誘導的毛囊新生]
DOI:10.3390/pharmaceutics14091926.
30. Wang HJ, Yeh JW, Chang YF, Wu JS, Yang CC*. Comorbid laboratory abnormalities in female pattern hair loss patients. Dermatologica Sinica, 2022 July-September. 40(3), pp. 174-177., pp. 178-181.
(Impa ct factor 1.321)
[Hair Follicle & Skin Appendages；女性型脫髮患者合併實驗室異常]
31. Lu HA, Yang CC, Chen YC. Three monthly doses of corticosteroid pulse therapy yields a satisfactory but temporary response in severe alopecia areata patients. Dermatologica Sinica,
2022 July-September. 40(3), pp. 178-181. (Impa ct factor 1.321)
[Hair Follicle & Skin Appendages；三個月劑量的皮質類固醇衝擊療法對嚴重斑禿患者產生令人滿意但暫時的反應。]
32. Syu GD*, Sutandy F.X. Reymondd, Chen Kevine, Cheng Yawei, Chen CS, Shih, Jean C. Autoantibody profiling of monoamine oxidase A knockout mice, an autism spectrum disorder model.
Brain, Behavior, and Immunity, 107, pp. 193-200. (Impa ct factor 19.227)
[Cancer & Others；自閉症譜系障礙模型單胺氧化酶 A 基因敲除小鼠的自身抗體分析。]
33. Hsiao, CY, Meng JL, Hong JZ, Ly XH, Lin MH, Chang CY,Nguyen, MTT., Cheng TL, Lin WW, Burnouf, Pierre-Alain, Al-Qaisi, Talal Saleme, Liu ES, Su YC. Engineering a High-Affinity
Anti-Methoxy Poly(ethylene glycol) (mPEG) Antibody for Sensitive Immunosensing of mPEGylated Therapeutics and mPEG Molecules. Bioconjugate Chemistry. 2022 Nov., 33, 11, 2180–2188.
(Impa ct factor 4.774)
[Cancer & Others；設計一種高親和力抗甲氧基聚乙二醇 (mPEG) 抗體，用於對 mPEG 化治療藥物和 mPEG 分子進行靈敏免疫傳感。]
DOI:10.1021/acs.bioconjchem.2c00416
34. Kuo CH*, Wu YF, Chang BI, Hsu CK, Lai CH, Wu HL. Interference in melanoma CD248 function reduces vascular mimicry and metastasis. Journal of Biomedical Science. 2022 Dec. 29(1), art. no. 98.
(Impact factor 8.41)
[Cancer & Others；黑色素瘤 CD248 功能的干擾可減少血管擬態和轉移]
DOI:10.1186/s12929-022-00882-3
35. Cheng PS, Hou PC, Yang CC, Chu CB. Variation of body regional responses to Ustekinumab and Secukinumab in psoriasis patients: A real-world retrospective study and literature review.
Dermatologic Therapy. 2022 Oct. (Impact factor 2.851)
[Hair Follicle & Skin Appendages；銀屑病患者對優特克單抗和蘇金單抗的身體區域反應的變化：一項真實世界的回顧性研究和文獻綜述]
36. Wen Fu-Lai. Expansion of ring-shaped supracellular contractile cables induces epithelial sheet folding. 2022 Dec. Vol. 106, Iss. 6.(Impact factor 2.707)
[Fibrosis & Regenerative Medicine；環形細胞上收縮索的擴張誘導上皮片折疊]
DOI:10.1103/PhysRevE.106.064403
37. Yen PT, Huang SE, Hsu JH, Kuo CH, Chao YY, Wang LS, and Yeh JL. Anti-Inflammatory and Antioxidative Effects of Puerarin in Postmenopausal Cardioprotection: Roles of Akt and Heme Oxygenase-1.
Am J Chinese Med. 2022 Nov 28;1-20. (Impact factor 6.005)
[Fibrosis & Regenerative Medicine; 抗發炎及抗氧化作用的葛根素(Puerarin)對於停經後期的心臟保獲作用機制與Akt及Heme Oxygenase-1有關]
DOI:10.1142/S0192415X2350009X.
38. Hsu YC, Chuang HC, Tsai KL, Tu TY, Shyong YJ, Kuo CH, Liu YF, Shih SS, and Lin CL*. Administration of N-Acetylcysteine to Regress the Fibrogenic and Proinflammatory Effects of Oxidative Stress
in Hypertrophic Ligamentum Flavum Cells. Oxidative Med Cell Longev. 2022 Oct 26;2022:1380353. eCollection 2022. (Impact factor 7.310)
[Fibrosis & Regenerative Medicine; 施用N-Acetylcsteine降低肥大性黃韌帶細胞中氧化壓力的纖維化和促炎作用。
39. Chi JY, Hsiao YW, Liang HY, Huang TH, Chen FW, Chen CY, Ko CY, Cheng CC, Wang JM*. Blockade of the pentraxin 3/CD44 interaction attenuates lung injury-induced fibrosis.
Clin Transl Med. 2022 Nov;12(11):e1099 (Impact factor 8.554)
[Fibrosis & Regenerative Medicine；阻斷 pentraxin 3/CD44 相互作用可減輕肺損傷引起的纖維化]
40. Meng-Wei Lin , Yu-Tzu Chang, Yuan-Yu Hsueh. Hyperosmolar Hyperglycemic Crisis After Burn Injury in a Patient With Advanced Amyotrophic Lateral Sclerosis: A Case Report. Annals of Plastic Surgery.
2022 Oct 1;89(4):373-375. (Impact factor 1.763)
[Hair Follicle & Skin Appendages；探討影響燒燙傷傷口癒合之代謝影響]
DOI:10.1097/SAP.0000000000003293
41. Liu WT, Sun PL, Bramono Kusmarinah, Ezmerli Mohammad, Yang CC, Chen WC. Annular infectious dermatoses. Clinics in Dermatology. 2022. 40. (5). 427-440 (Impact factor 3.541)
[Mechanobiology & Skin Disease；環狀感染性皮膚病]
DOI:10.1016/j.clindermatol.2021.12.006
42. Miyake Tomoko, Natsuga Ken, Umayahara Takatsune, Naito Seikoc, Yoshimoto Junko, Senoo Akemi, Wang HT, Hsu CK, Yamasaki Osamu, Morizane Shin. Case of inherited epidermolysis bullosa simplex
with KLHL24 gene mutation in Japan. Journal of Dermatology. 2022. 49. (1). 24-25. (Impact factor 3.468)
[EB & genetic diseases；日本KLHL24基因突變的遺傳性單純性大皰性表皮鬆解症一例]
43. Hong YK*, Wu CH, Lin YC, Huang YL, Hung KS, Pai TP.Liu YT, Chen TC, Chan H, Hsu CK. ASC-J9 Blocks Cell Proliferation and Extracellular Matrix Production of Keloid Fibroblasts through Inhibiting
STAT3 Signaling. International Journal of Molecular Sciences. 2022. 23. (10). (Impact factor 5.542)
[Fibrosis & Regenerative Medicine；ASC-J9 通過抑制 STAT3 信號傳導阻斷瘢痕疙瘩成纖維細胞的細胞增殖和細胞外基質產生]
44. Harn, Hans I-Chena, Chiu PY, Lin CH, Chen HY, Lai YC, Yang S, Wu CC, Tang MJ, Chuong Cming, Hughes, Michael W. Topological Distribution of Wound Stiffness Modulates Wound-Induced Hair Follicle Neogenesis.
Pharmaceutics. 2022. 14. (9). (Impact factor 6.072)
[Hair Follicle & Skin Appendages；傷口剛度的拓撲分佈調節傷口誘導的毛囊新生]
DOI:10.3390/pharmaceutics14091926
45. Chen HH, Fu-Nienb, Yang CC. Mucocutaneous hyperpigmentation as a clue to diagnose Addison disease-Two case reports. Dermatologica Sinica. 2022. 40. (1). 48-49(Impact factor 1.321)
[Mechanobiology & Skin Disease；皮膚黏膜色素沉著作為診斷艾迪生病的線索——附二例報告]
46. Yang HS, Hsu CK, Lee Julia YY, Chang, SS. Immunohistochemical and molecular studies of the resolved cutaneous Kaposi sarcoma in a kidney transplant recipient: A clinicopathological observation.
Asian Journal of Surgery. 2022. 45. (10). 1980-1981 (Impact factor 2.767)
[Mechanobiology & Skin Disease；腎移植受者皮膚卡波西肉瘤的免疫組織化學和分子研究：臨床病理學觀察]
DOI:10.1016/j.asjsur.2022.04.044
47. Hsu TC, Yu PH, Chang YH, Guevara, Bryan Edgar K, Tsai MC, Yang MH, Tsai PY, Lee Julia YY, Chao SC, Hsu CK. Novel compound heterozygous indel ZMPSTE24 mutations in a Taiwanese male infant
with restrictive dermopathy. Journal of Dermatology. 2022. 49. (8). 280-282. (Impact factor 3.468)
[EB & genetic diseases；患有限制性皮膚病的台灣男嬰的新型複合雜合插入缺失 ZMPSTE24 突變]
48. Chen YF, Lu HC, Hou PC, Lin YC, Aala Wilsonf, Onoufriadis Alexandros, McGrath John A., Chen YL, Hsu CK. Plasma metabolomic profiling reflects the malnourished and chronic inflammatory state
in recessive dystrophic epidermolysis bullosa. Journal of Dermatological Science. 2022. 107. (2). 82-88 (Impact factor 4.563)
[EB & genetic diseases；血漿代謝組學分析反映了隱性營養不良性大皰性表皮鬆解症的營養不良和慢性炎症狀態]
DOI:10.1016/j.jdermsci.2022.07.006
49. Chang YH, Yang HS, Huang HY, Lee Julia YY, Hsu CK. A possible role for second-hit postzygotic GJB2 mutation in porokeratotic eccrine ostial and dermal duct nevus. Journal of Dermatology. 2022. ISSN: 03852407.
(Impact factor 3.468) [EB & genetic diseases；汗孔角化性小汗腺開口和真皮導管痣中二次擊中合子後 GJB2 突變的可能作用]
50. Tu WT, Hou PC, Chen PC, Chen WR, Huang HY, Wang JY, Huang YT, Wu YH, Su CL, Tang YA, Iwata, Hiroakih, Natsuga, Ken, Chao SC, Sun, H. Sunny, Tang MJ, Lee JYY, McGrath, John A., Hsu CK.
Mutational analysis of epidermolysis bullosa in Taiwan by whole-exome sequencing complemented by RNA sequencing: a series of 77 patients. Orphanet Journal of Rare Diseases. 2022. 12. 1(17). ISSN:17501172(Impact factor 3.453)
[EB & genetic diseases；通過全外顯子組測序輔以 RNA 測序對台灣大皰性表皮鬆解症的突變分析：77 例患者係列]
DOI: 10.1186/s13023-022-02605-1
51. Lin YC, Chang YH, Chiu Frank Po-Chao, Akiyama, Masashie, Hsu CK. Application of nanopore sequencing in identifying null mutations and intragenic copy number variations (CNVs) in FLG.
Journal of Dermatological Science. 2022. October. 1(108). 48-50. ISSN:09231811(Impact factor 4.563) [EB & genetic diseases；納米孔測序在鑑定 FLG 中的無效突變和基因內拷貝數變異 (CNV) 中的應用]
DOI:10.1016/j.jdermsci.2022.09.004
52. Du JY, Lai HY, Hsiao YW, Chi JY, Wang JM. Pentraxin 3 Facilitates Shrimp-Allergic Responses in IgE-Activated Mast Cells. Journal of Immunology Research. 2022. (Impact factor 4.818)
[Cancer & Others；Pentraxin 3 促進 IgE 激活的肥大細胞中的蝦過敏反應]
2021年國際期刊論文(共37篇，IF 值＞6之高影響力期刊13篇)
1. Wong TW, Yang CC, Hsu CK, Liu CH, Lee JYY. Transplantation of autologous single hair units heals chronic wounds in autosomal recessive dystrophic epidermolysis bullosa: A proof-of-concept study. J Tissue Viability.
2021 Feb;30(1): 36-41. (Impact Factor:2.82)
[Wound Healing & Plastic Surgery；利用植髮手術治療泡泡龍病患的難癒合傷口。]
2. Huang HP, Hsu CK, Lee JYY. Rosacea with persistent facial erythema and high Demodex density effectively treated with topical ivermectin alone or combined with oral carvedilol. Dermatol Ther. 2021 Feb 18; e14899.
[Online ahead of print]. (Impact Factor:2.388)
[Skin Diseases；證實局部塗抹殺蟲藥劑ivermectin可以減少蠕形蟎蟲在皮膚的密度，進而改善玫瑰斑的臨床症狀。]
3. Lee CN, Chiu FPC, Hsu CK. Cutaneous cytomegalovirus (CMV) infection in a patient with metastasized lung cancer. Clin Microbiol Infect. 2021 Jan 30;S1198-743X(21)00043-4. [Online ahead of print]. (Impact Factor:7.117)
[Cancer & Others；報導一位使用標靶藥物治療的肺癌患者出現CMV的感染。]
4. Hung JH, Hou PC, Huang FC, Hsu CK. Topical gentamicin ointment induces LAMB3 nonsense mutation readthrough and improves corneal erosions in a patient with junctional epidermolysis bullosa. Clin Exp Ophthalmol.
2021 Feb 26. (Impact Factor:2.832)
[EB & genetic diseases；第一個利用局部塗抹gentamicin藥膏減緩LAMB3 nonsense mutation的結合型泡泡龍病友的眼睛症狀。]
5. Chen YC, Huang YT, Yang CC, Lai EC, Liu CH, Hsu CK, Wong TW, Chao SC, Sheu HM, Lee CN. Real-world efficacy of biological agents in moderate-to-severe plaque psoriasis: An analysis of 75 patients in Taiwan. PLoS One.
2020 Dec 15(12): e0244620, 2020. journal.pone.0244620. (Impact Factor:3.240)
[Cancer & Others；乾癬是一種表皮增生的疾病，其致病過程與生物機械力相關，我們目前正進行研究，此論文整理皮膚科乾癬病人的臨床表現。]
DOI:10.1371/journal.pone.0244620
6. Yang CC*, Wu CH, Wong TW, Lai FJ, Wei KC, Lin TK, Lin CS, Zhao J, Xiang L, Kao CH, Wang YJ, Lan CE, Sheu HM. Effects of Solanum undatum extract (SR-T100) on photocarcinogenesis and photoaging of actinic keratosis. J
Dermatol. 2021 Jan 48 (3): 344–352. (Impact Factor:3.072)
[Cancer & Others；與中國上海復旦大學華山醫院共同進行研究。日光性角化症為早期的皮膚癌，皮膚老化及日光性角化症的成因與物理性紫外線照射有關，本研究探討黃水茄萃取物對日光性角化症的治療效果。]
7. Chang LY, Lai CH, Kuo CH, Chang BI, Wu HL, Cheng TL. Recombinant thrombomodulin lectin-like domain attenuates porphyromonas gingivalis lipopolysaccharide-induced osteoclastogenesis and periodontal bone resorption. J
Periodontol. 2021 Jan 12. (Impact Factor:3.742)
[Wound Healing & Regenerative Medicine；以重組蛋白治療內毒素誘發之發炎反應及骨質流失之分子機制及建立臨床前實驗動物模式探討。]
8. Kuo CH*, Huang YH, Chen PK, Lee GH, Tang MJ, Conway EM, Shi GY, Wu HL*. VEGF-induced endothelial podosomes via ROCK2-dependent thrombomodulin expression initiate sprouting angiogenesis.
Arterioscler Thromb Vasc Biol. 2021 Mar 18:ATVBAHA121315931. (Impact Factor:6.604)
[Wound Healing & Regenerative Medicine；與加拿大UBC Centre for Blood Research國際合作，研究傷口癒合及組織重建過程血管新生的起始分子機制。]*Coresponding author
DOI:10.1161/ATVBAHA.121.315931
9. Harn HI, Chen CC, Wang SP, Lei M, Chuong CM. Tissue Mechanics in Haired Murine Skin: Potential Implications for Skin Aging. Front Cell Dev Biol. 2021 Feb 19;9:635340. eCollection 2021. (Impact Factor: 5.186)
[ Mechanobiology & Skin Disease；從機械力學的角度探討皮膚老化和傷口癒合與再生。]
10. Harn HI, Wang SP, Lai YC, Van Handel B, Liang YC, Tsai S, Schiessl IM, Sarkar A, Xi H, Hughes M, Kaemmer S, Tang MJ, Peti-Peterdi J, Pyle A, Woolley TE, Evseenko D, Jiang TX, Chuong CM. Symmetry breaking of tissue
mechanics in wound induced hair follicle regeneration of laboratory and spiny mice. Nature Communications. 10 May 2021. (Impact Factor: 12.121)
[Mechanobiology & Skin Disease；比較非洲刺鼠和實驗鼠傷口毛髮再生過程中組織機械力扮演角色，找出傷口毛髮再生過程中最佳的組織機械力為5-15kPa。]
DOI:10.1038/s41467-021-22822-9
11. Wang SM, Lin WC, Lin HY, Chen YL, Ko CY, Wang JM. CCAAT/Enhancer-binding protein delta mediates glioma stem-like cell enrichment and ATP-binding cassette transporter ABCA1 activation for temozolomide resistance in
glioblastoma. Cell Death Discov. 2021 Jan 12;7(1):8. (Impact Factor: 4.114)
[Biomaterials & Stem Cells；從藥物引發類發炎反應的模式的建立,解析發炎問題誘發活化的轉錄因子CEBPD參與多形性膠質母細胞瘤抗藥性形成]
DOI:10.1038/s41420-020-00399-4
12. Lai HY, Tsai HH, Yen CJ, Hung LY, Yang CC, Ho CH, Liang HY, Chen FW, Li CF, Wang JM. Metformin Resensitizes Sorafenib-Resistant HCC Cells Through AMPK-Dependent Autophagy Activation. Front Cell Dev Biol. 2021 Jan
21;8:596655. (Impact Factor: 5.186)
[Biomaterials & Stem Cells；從藥物引發類發炎反應的模式的建立,解析抗血脂藥物metfomin如何活化自噬作用參與抗藥性形成]
13. Wang TY†, Chang MM†, Li J,Huang TC,Chien S,Wu CC#. Maintenance of HDAC and H3K9me3 Prevents Arterial Flow-Induced Venous Endothelial Damage. Frontiers in Cell and Developmental Biology, 09 Apr 2021, 9:642150.
(Impact Factor: 6.684)
[Biomaterials & Stem Cells；與美國加州大學聖地牙哥分校錢煦院士合作，探討靜脈在血管移植(心繞道手術或透析病人瘻管) 後承受動脈血流所產生的發炎、靜脈細胞流失、血管再粥狀硬化等副作用的機制，
同時亦探討修復受損靜脈之治療策略，以延長移植靜脈的使用年限。]
DOI:10.3389/fcell.2021.642150.
14. Chen SH, Wu CC, Lin SC, Tseng WL, Huang TC, Anjali Yadav, Lu FI, Liu YH, Lin SP, Hsueh YY*, Investigation of neuropathology after nerve release in chronic constriction injury of rat sciatic nerve. International Journal of
Molecular Sciences 2021; 22(9):4746-4763 (Impact Factor: 5.923)
[Mechanobiology; Wound Healing &;Plastic Surgery; 在此研究發現,受物理性壓迫的周邊神經在減壓後，會對於周邊神經的化學性訊號、神經發炎甚至其表關遺傳學皆有影響]
15. Du PX, Chou YY, Santos HM, Keskin BB, Hsieh MH, Ho TS, Wang JY, Lin YL, Syu GD*. Development and application of human coronavirus protein microarray for specificity analysis. Analytical Chemistry. 2021; In Press.
(Impact factor 6.785)
[Fibrosis & Regenerative Medicine；探討冠狀病毒感染後的免疫反應，以及呼吸道細胞的修復再生。*corresponding author]
DOI:10.1021/acs.analchem.1c00614
16. Yang CC, Yen YY, Hsu CK, Cheng NY, Tzeng SY, Chou SJ, Chang JM, Tseng SH. Investigation of water bonding status of normal and psoriatic skin in vivo using diffuse reflectance spectroscopy. Sci Rep. 2021 Apr 26;11(1):8901.
(Impact factor 3.999)
[Mechanobiology & Skin Disease; 使用漫反射光譜測量皮膚表面含水量，在乾癬病人皮膚的變化，含水量會改變皮膚的物理性質及機械力。]
DOI:10.1038/s41598-021-88530-y
17. Lin PY, Hung JH, Hsu CK, Chang YT, Sun YT, A Novel Pathogenic HSPG2 Mutation in Schwartz–Jampel Syndrome. Front. Neurol., 09 March 2021. (Impact factor 3.184)
[EB & genetic diseases；與神經內科團隊合作完成Schwartz–Jampel Syndrome的基因檢測]
18. Hou PC, Tu WT, Chen PC, Bryan Edgar K Guevara,Yen YF, Huang HY, Julia Yu-Yun Lee, Tang MJ, Kuo PL, John A Mcgrath , Hsu CK. A de novo COL17A1 splice-site mutation causing a 7-bp deletion in a Taiwanese patient with
junctional epidermolysis bullosa. European Journal of Dermatology. 2021 Apr., 31(2):267-269. (Impact factor 2.782)
[EB & genetic diseases；在台灣泡泡龍病患身上找到獨特的COL17A1基因異常位點]
19. Wang CW, Wichittra Tassaneeyakul, Chen CB, Chen WT, Teng YC, Huang CY, Chonlaphat Sukasem, Lu CW, Lee YS, Choon SE, Nontaya Nakkam, Rosaline Hui CY, Huang YH, Chang YC, Yang Yu-Wei Lin, Chang CJ, Chiu TM,
Wasun Chantratita, Parinya Konyoung, Lee CN, Jettanong Klaewsongkram, Ticha Rerkpattanapipat, Warayuwadee Amornpinyo, Niwat Saksit, Pawinee Rerknimitr, Huang YH, Lin SH, Hsu CK, Chan CC, Lin YJ, Hung SI,
Chung WH. Whole genome sequencing identifies genetic variants associated with co-trimoxazole hypersensitivity in Asians. Journal of Allergy and Clinical Immunology. 2021 Apr., 147(4):1402-1412. (Impact factor 10.228)
[EB & genetic diseases；跨院合作利用次世代基因定序找出co-trimoxazole引發藥物過敏的致病基因]
DOI:10.1016/j.jaci.2020.08.003
20. Hung JH, Wang CT, Lee CN, Shieh SJ. Unilateral Vision Loss After Hyaluronic Acid Injection: A Case Report. Ann Plast Surg 2021 Feb 1;86(2S Suppl 1):S127-S131. (Impact factor 1.354)
[Wound Healing & Plastic Surgery; 回顧了有關化妝品填充劑注射後不良事件的管理，包括輕微的皮膚病變，如局部腫塊和結節、變色和免疫反應。]
DOI:10.1097/SAP.0000000000002624
21. Hung KS, Hsu HY, Kuo LC, Chang JH, Lee YC, Ho CL, Pan SC, Shieh SJ. Dynamic Traction Splint as an Alternative Surgical Treatment for Comminuted Intraarticular Fracture of Metacarpophalangeal Joint. Ann Plast Surg
2021 Feb 1;86(2S Suppl 1):S35-S40. (Impact factor 1.354)
[Wound Healing & Plastic Surgery; 動態牽引夾板和術後康復計劃可能是掌指關節內粉碎性骨折的替代治療方法。]
DOI:10.1097/SAP.0000000000002661
22. Wang WJ, Lai HY, Zhang F, Shen WJ, Chu PY, Liang HY, Liu YB, Wang JM*. MCL1 participates in leptin-promoted mitochondrial fusion and contributes to drug resistance in gallbladder cancer. JCI Insight.
2021 Aug 9;6(15):e135438. (Impact Factor: 8.315 )
[Cancer & Others；成大與中國醫合作，針對膽囊癌周邊脂肪細胞如何藉由內分泌激素 leptin，影響癌細胞內粒腺體融合及參與抗藥性形成，並且同步提供克制該抗藥性形成路徑的治療策略。]
DOI:10.1172/jci.insight.135438
23. Chu CB, Yang CC, Tsai SJ. Global data analysis supports smoking as the fundamental element associated with geographical sex disparities in hidradenitis suppurativa. Br J Dermatol. 2021 Jun 15.
Epub ahead of print. PMID: 34128538. (Impact Factor: 9.302)
[Hair Follicle & Skin Appendages；研究毛囊引起的發炎反應及皮膚纖維化與抽菸的相關性。]
24. Lo TK, Yang CC, Lee JY, Hsu CK. Serial punch excisions followed by second-intention healing for acne keloidalis papules. J Am Acad Dermatol. 2021 Aug 14:S0190-9622(21)02265-9. j.jaad.2021.07.061.
Epub ahead of print. PMID: 34403706. (Impact Factor: 11.527)
[Fibrosis & Regenerative Medicine；針對acne keloidalis這一種疤痕性落髮疾病的新手術治療方法。]
DOI:10.1016/j.jaad.2021.07.061
25. Chu CB, Li WL, Lin SH, Hsu CK, Yang CC*, Tsai SJ. The influence of gender and smoking on hidradenitis suppurativa: A retrospective study of 161 patients in Taiwan. Dermatol Sin 39:125-31, 2021. (Impact Factor: 1.321)
[Hair Follicle & Skin Appendages；研究毛囊引起的發炎反應及皮膚纖維化與抽菸的相關性。]
26. Wang YA, Lee JY, Yang CC. Sustainable effect of ultra-low dose rituximab for mild-to-moderate pemphigus vulgaris: A case report. J Dermatol. 2021 Sep 14. Epub ahead of print. PMID: 34519062. (Impact Factor: 4.005)
[Mechanobiology & Skin Disease；研究天皰瘡水泡病的新治療方法。]
27. Hou PC, Wang HT, Abhee S, Tu WT, McGrath JA, Hsu CK*. Investigational Treatments for Epidermolysis Bullosa. Am J Clin Dermatol. 2021 Jul 22. [Online ahead of print.] (Impact Factor: 7.403)
[EB & genetic diseases；大皰性表皮鬆解症的研究性治療。]
DOI:10.1007/s40257-021-00626-3
28. Hou PC, Natsuga K, Tu WT, Huang HY, Chen B, Chen LY, Chen WR, Hong YK, Tang YA, Lee JY, Chen PC, Sun HS, McGrath JA, Hsu CK*. Complexity of Transcriptional and Translational Interference of Laminin-332 Subunits in
Junctional Epidermolysis Bullosa with LAMB3 Mutations. Acta Derm Venereol. 2021 Aug 24;101(8):adv00522 (Impact Factor: 4.016)
[EB & genetic diseases；大皰性表皮鬆解症診斷遺傳學。]
29. Huang YH, Kuo CH, Pen IC, Chang YS, Tseng SH, Conway EM, Wu HL. Recombinant thrombomodulin domain 1 rescues pathological angiogenesis by inhibition of HIF-1α-VEGF pathway. Cell. Mol. Life Sci. 2021 Oct 27.
Online ahead of print. (Impact Factor 9.261)
[Neurovascular Regenerative Medicine；與加拿大British Columbia University合作，探討視網膜病變過程異常血管新生的機制及發展並對比於現行的治療方法，結果顯示重組凝血酶調節素第一功能區域蛋白具有降低
不正常血管新生的能力，其抑制不正常血管的能力與現行的治療方法是可以達到相同的治療效果，然而在抑制發炎的調控方面是優於現行的治療策略，本研究結果呈現出以重組凝血酶調節素第一功能區域蛋白作
為治療血管病變的可能性。]
DOI:10.1007/s00018-021-03950-3
30. A. Y. Yadav, T. C. Huang, S. H Chen, T. S. Ramasamy, Y. Y Hsueh, S. P. Lin, F. I. Lu, Y.H. Liu ,C. C. Wu. Sodium phenylbutyrate inhibits Schwann cell inflammation via HDAC and NFκB to promote axonal regeneration and
remyelination. Journal of Neuroinflammation. 18r: 238. (Impact Factor 8.322)
[Neurovascular Regenerative Medicine；使用 PBA 治療抑制炎症的延長狀態有利於神經橫斷損傷後的軸突再生和髓鞘再生。]
DOI:10.1186/s12974-021-02273-1
31. Grieve AG, Yeh YC, Chang YF, Huang HY, Zarcone L, Breuning J, Johnson N, Strisovsky K, Brown MH, Parekh AB, Freeman M. Conformational surveillance of Orai1 by a rhomboid intramembrane protease prevents inappropriate
CRAC channel activation. Mol Cell (Accepted, Nov, 2021) (Impact Factor 17.97)
[Cancer & Others；與英國牛津大學合作，探討細胞膜蛋白酶RHBDL2如何辨識不正常活化的鈣離子通道CRAC channel，並降解其細胞膜上蛋白Orai1。]
DOI:10.1016/j.molcel.2021.10.025
32. Yu CJ, Dian W. Damaiyanti, Yan SJ, Wu CH, Tang MJ, Shieh DB, Peter P. Liu, Liu PY. The pathophysiologic role of gelsolin in chronic kidney disease: Focus on podocytes. Int. J. Mol. Sci. 2021, 22(24), 13281
(Impact Factor 5.923)
[Fibrosis & Regenerative Medicine；凝溶膠蛋白在慢性腎病中的病理生理作用：關注足細胞]
33. Wen FL, Chun WK,Wang YC,Tatsuo Shibata. Autonomous epithelial folding induced by an intracellular mechano–polarity feedback loop. December 6, 2021. plos computational biology. (Impact Factor 4.71)
[Mechanobiology & Skin Disease；與日本神戶理化學研究所生物系統動力學研究中心合作，由細胞內機械-極性反饋迴路誘導的自主上皮折疊]
DOI:10.1371/journal.pcbi.1009614
34. Ken Natsuga, Satoru Shinkuma, Hsu CK, Yasuyuki Fujita, Akira Ishiko, Katsuto Tamai, John A McGrath. Current topics in Epidermolysis bullosa: Pathophysiology and therapeutic challenges. Journal of Dermatological Science.
Volume 104, Issue 3, December 2021, Pages 164-176. (Impact Factor 4.563)
[EB & genetic diseases；與日本5個不同醫學機構皮膚科專家及英國倫敦國王大學合作，探討大皰性表皮鬆解症(EB)在病理生理學和治療挑戰。]
DOI:10.1016/j.jdermsci.2021.11.004
35. Chu CB, Yang CC, Tsai SJ. Hidradenitis suppurativa: Disease pathophysiology and sex hormones. Chinese Journal of Physiology, 2022 Nov-Dec; 64(6), 257-265.(Impact Factor 1.71)
[Hair Follicle & Skin Appendages；化膿性汗腺炎：疾病病理生理與性激素]
36. Wei KC, Yang CC. Hair loss and COVID-19. Dermatologica Sinica, 2021 October-December; 39(4), pp. 167-168. (Impact Factor 1.321)
[Hair Follicle & Skin Appendages；脫髮和 COVID-19]
37. Liu WT,Sun PL, KusmarinahBramono, MohammadEzmerli, Yang CC, Chen WC. Annular infectious dermatoses. Clinics in Dermatology. 2021 Dec. (Impact Factor 3.541)
[Mechanobiology & Skin Disease；環狀傳染性皮膚病]
DOI:10.1016/j.clindermatol.2021.12.006
2020年國際期刊論文(共23篇，IF 值＞6之高影響力期刊9篇)
1. Chen KY, Lin SH, Cheng SY, Lo TK, Huang HY, Tang MJ, Yang CC*. Androgenetic alopecia is associated with increased scalp hardness. J Eur Acad Dermatol Venereol. 2020 Jan 15. Online ahead of print.
(Impact Factor: 5.248)
[Hair Follicle & Skin Appendages; 此文章闡述頭皮硬度與禿髮的關聯性，是否皮膚纖維化造成頭皮硬度增加是禿髮的原因，值得深究。]
2. Cheng AY, Lee CN, Hsieh FN, Lo TK, Huang HY, Hsu CK, Lee JYY, Yang CC*. “Spade sign” and inflammation/fibrosis limited to the upper and mid‐dermis as the pathognomonic features of acne keloidalis.
J Dermatol 2020 Jan;47(1):41-46. (Impact Factor: 3.072)
[Hair Follicle & Skin Appendages; 此文章探究acne keloidalis這種特殊禿髮疾病，探究其頭皮發炎、纖維化而最後疤痕性禿髮的過程及機制]
3. Fang J, Hsueh YY, Soto J, Sun W, Wang J, Gu Z, Khademhosseini A, Li S. Engineering Biomaterials with Micro. Nanotechnologies for Cell Reprogramming. ACS NANO. 2020 Feb 25;14(2):1296-1318.
(Impact Factor: 14.588)
[Fibrosis & Regenerative Medicine；與美國加州大學洛杉磯分校國際合作，探討使用生物醫學材料合併微奈米科技來促使細胞重編程，以及對於組織工程以及再生醫學的應用。]
4. Pan SC, Tsai YH, Chuang CC, Cheng CM. Preliminary Assessment of Burn Depth by Paper-Based ELISA for the Detection of Angiogenin in Burn Blister Fluid—A Proof of Concept.
Diagnostics 2020 Mar;10(3):127 (1-10) (Impact Factor: 3.110)
[Wound Healing & Plastic Surgery；在此文章中，我們利用紙基質試紙檢測燒傷水泡液內的特殊因子血管生成素，藉由這項檢測可早期診斷傷口的嚴重度，進而採取積極的治療]
DOI:10.3390/diagnostics10030127
5. Yen CF, Hsu CK, Yang HS, Lee CN, Chi CC, Chung WH, Wang CL, Pang JS, Wang CW, Ko YS, Lu CW. Treatment of epidermal growth factor receptor inhibitor-induced severe paronychia with pyogenic granuloma-like
lesions with topical betaxolol: an open-label observation study. Int J Dermatol. 2020 Mar;59(3):326-332. (Impact Factor: 2.067)
[Skin Diseases；與長庚醫院皮膚科醫師合作，利用青光眼藥水治療EGFRi標靶藥物治療引發的皮膚副作用]
6. Yang HS, Guevara BEK, Lee KT, Wu CL, JYW Lee, Hsu CK*. Lupus erythematosus/lichen planus overlap syndrome in a breast cancer patient receiving aromatase inhibitor: A case report and review of the literature.
Dermatologica Sinica. 2020 Apr 1;38(2):129-130. (Impact Factor: 0.921)
[Skin diseases；與乳房外科醫師合作，報告病患使用乳癌用藥之後出現的皮膚副作用]
7. Supsrisunjai C, Hsu CK, Michael M, Duval C, Lee JYW, Yang HS, Huang HY, Chaikul T, Onoufriadis A, Steiner RA, Ariëns RAS, Sarig O, Sprecher E, Schwartz-Eskin M, Samlaska C, Simpson MA, Calonje E, Parsons M,
McGrath JA*. Coagulation factor XIII-A subunit missense mutation in the pathobiology of autosomal dominant multiple dermatofibromas. J Invest Dermatol. 2020 Mar;140(3):624-635. (Impact Factor: 7.143)
[EB & Genetic Diseases；與英國倫敦國王大學合作，在美國以及烏克蘭的皮膚性纖維瘤病患，找到Factor XIII-A的基因異常]
8. Solis MA, Huang LLH*. Hyaluronan induces a mitochondrial functional switch in fast-proliferating human mesenchymal stem cells. International J Stem Cells 2020 Mar; 13(1):151-162. (Impact Factor: 1.940)
[Biomaterials & Stem Cells；透明質酸可以影響幹細胞增生時之粒線體功能。]
9. Chen SH, Huang TC, Wang JY, Wu CC, Hsueh YY*. Controllable forces for reproducible chronic constriction injury mimicking compressive neuropathy in rat sciatic nerve. Journal of Neuroscience Methods.
2020 Apr 1;335:108615. (Impact Factor: 2.39)
[Mechanobiology; Wound Healing & Plastic Surgery; 在此文章中，我們發現經由調控周邊神經壓迫的力量，可以分別影響感覺以及運動神經病變，且符合臨床神經病變的不同等級]
DOI:10.1016/j.jneumeth.2020.108615
10. Huang HP, Hsu CK, Lee JY. A new superficial needle-scraping method for assessing Demodex density in papulopustular rosacea. J Cosmet Dermatol. 2020 Apr;19(4):896-900. (Impact Factor: 1.612)
[Skin diseases；與診所醫師合作，研發診斷蠕形蟎蟲的方式]
11. Wu YT, Wu YT, Huang TC, Su FC, Jou IM, Wu CC*. Sequential inflammation model for Achilles tendinopathy by elastin degradation with treadmill exercise. Journal of Orthopaedic Translation. 2020 Jul; 23:113-121.
(Impact Factor: 5.191)
[Cancer & Others；建立離體彈性纖維蛋白降解引起的肌腱細胞炎症動物模式，以了解消化酶對彈性纖維蛋白降解的影響以及肌腱細胞炎症反應的誘導。]
12. Yang T, Pan SC*, Cheng CM. Paper-based human neutrophil elastase detection device for clinical wound monitoring. LAB ON A CHIP. 2020 Aug 7; 20(15):2709-2716 (Impact Factor: 6.774)
[Wound Healing &Plastic Surgery; 本文我們利用紙基質試紙檢測急慢性傷口內之中性白細胞彈性蛋白酶，藉由這項檢測可區別傷口的嚴重度，進而採取適當治療方法]
13. Yang T, Pan SC, Cheng CM. Paper-based detection device for chronic wound monitoring. Health and Technology. 2020 Aug 2020;4:1-5. doi: 10.21037/ht-20-6. (Impact Factor: 1.120)
[Wound Healing & Plastic Surgery; 本文乃對紙基質試紙檢測慢性傷口的優勢做綜合性的評論。紙基質試紙檢測傷口的好處在於可快速且正確的診斷傷口的嚴重度。另外，便宜及操作容易也是它的優勢之一。]
14. Chuamanochan M, Onoufriadis A, Farnood S, Hsu CK, Simpson MA, Mahanupab P, Tovanabutra N, Chiewchanvit S, McGrath JA*. Blaschko-linear lichen planus: Clinicopathological and genetic analysis.
J Dermatol. 2020 Aug 12;47(11): E384-E385. (Impact Factor:3.072)
[EB & Genetic Diseases；與英國King’s College London合作，利用次世代基因定序探討Blaschko-linear lichen planus的基因致病機轉]
15. Tu WT, Chen PC, Hou PC, Huang HY, Wang JY, Chao SC, Lee JY, McGrath JA, Natsuga K, Hsu CK*. Plectin missense mutation p.Leu319 Pro in the pathogenesis of autosomal recessive epidermolysis bullosa simplex.
Acta Dermato-Venereologica. 2020 Aug 18; 100(15): adv00242. (Impact Factor: 4.016)
[EB & Genetic Diseases；與日本北海道大學以及英國倫敦國王大學合作，利用in vitro study證實plectin misesense mutation 也會造成臨床的水泡症狀]
16. Syu GD* (*first and corresponding authors), Dunn J, Zhu H. Developments and applications of functional protein microarrays. Mol Cell Proteomics. 2020 Aug; 19:916-927. (Impact factor 4.870)
[Hair Follicle & Skin Appendages；此文章闡述頭蛋白質晶片應用於免疫與分子檢測，可透過該技術檢測禿髮以及細胞纖維化的原因與免疫機制，值得深究。]
17. Syu GD* (first and corresponding authors), Johansen E, Zhu H*. Virion Display: A High-Throughput Method to Express Functional Membrane Proteins. Current Protocols in Molecular Biology. 2020 Sep 23; 132:e126.
(Impact Factor: 1.240)
[Hair Follicle & Skin Appendages；此文章闡述頭膜蛋白晶片應用於訊號傳遞的測量，可透過該技術檢測禿髮以及細胞纖維化的成因與機制。]
18. Kosumi H, Natsuga K*, Takashima S, Miyauchi T, Huang YT, Nomura T, Yanagi T, Huang HY, Chiu FP, Chen PC, Hsu CK, Shimizu H. Two cases of interleukin-7 (IL-7)-deficient generalized verrucosis.
Clin Infect Dis. 2020 Sep 15; 12;71(6):1561-1563. (Impact Factor: 8.313)
[EB & Genetic Diseases；與日本北海道大學國際合作，利用次世代基因定序找出多發性病毒疣患者的致病基因IL7]
19. Murrell DF, Lucky AW, Salas-Alanis JC, Woodley DT, Palisson F, Natsuga K, Nikolic M, Ramirez-Quizon M, Paller AS, Lara-Corrales I, Barzegar MA, Sprecher E, Has C, Laimer M, Bruckner AL, Bilgic A, Nanda A,
Purvis D, Hovnanian A, Murat-Sušić S, Bauer J, Kern JS, Bodemer C, Martin LK, Mellerio J, Kowaleski C, Robertson SJ, Bruckner-Tuderman L, Pope E, Marinkovich MP, Tang JY, Su J, Uitto J, Eichenfield LF, Teng J,
Aan Koh MJ, Lee SE, Khuu P, Rishel HI, Sommerlund M, Wiss K, Hsu CK, Chiu TW, Martinez AE. Multidisciplinary care of epidermolysis bullosa during the COVID-19 pandemic-Consensus: Recommendations by an
international panel of experts. J Am Acad Dermatol. 2020 Oct;83(4):1222-1224. (Impact Factor:8.277)
[EB & Genetic Diseases；加入世界EB專家團隊，制定COVID-19期間對於泡泡龍患者的治療建議]
DOI:10.1016/j.jaad.2020.06.1023
20. Huang CW, Lu SY, Huang TC, Huang BM, Sun HS, Yang SH, Chuang JI, Hsueh YY, Wu YT, Wu CC*. FGF9 induces functional differentiation to Schwann cells from human adipose derived stem cells.
Theranostics. 2020 Oct;10(6):2817-2831. (Impact Factor: 11.556)
[Fibrosis & Regenerative Medicine；建立離體彈性纖維蛋白降解引起的肌腱細胞炎症動物模式，以了解消化酶對彈性纖維蛋白降解的影響以及肌腱細胞炎症反應的誘導。]
21. Choi YS#, Hsueh YY#, Koo J, Yang Q, Avila R, Hu B, Xie Z, Lee G, Ning Z, Liu C, Xu Y, Lee YJ, Zhao W, Fang J, Deng Y, Lee SM, Vázquez-Guardado A, Stepien I, Yan Y, Song JW, Haney C, Oh YS, Liu W, Yun HJ, Banks A,
MacEwan MR, Ameer GA, Ray WZ, Huang Y, Xie T, Franz CK, Li S, Rogers JA. Stretchable, dynamic covalent polymers for soft, long-lived bioresorbable electronic stimulators designed to facilitate neuromuscular regeneration.
Nature Communications. 2020 Nov; 11(1):5990-6003. (Impact Factor: 12.121)
[Fibrosis & Regenerative Medicine；與美國加州大學洛杉磯分校與芝加哥西北大學國際合作，探討使用可吸收生物電子裝置來給予重複神經電刺激，來促進神經肌肉介面的再生與功能恢復。]
DOI:10.1038/s41467-020-19660-6
22. Yang T, Pan SC*, Cheng CM. Paper-based human neutrophil elastase detection device for clinical wound monitoring. Lab Chip, 2020 Aug, 20, 2709-2716 , *Corresponding author (Impact Factor: 12.121)
[Wound Healing & Plastic Surgery；利用紙基質試片檢測慢性傷口中之特殊物質]
23. Huang TC, Wu HL, Chen SH, Wang YT, Wu CC.Thrombomodulin facilitates peripheral nerve regeneration through regulating M1/M2 switching. J Neuroinflammation. 2020 Aug 14;17(1):240. (Impact Factor: 8.322)
[Wound Healing & Regenerative Medicine；血栓調節蛋白通過調節 M1/M2 轉換促進外周神經再生。]
DOI:10.1186/s12974-020-01897-z
2019年國際期刊論文(共23篇，IF 值＞6之高影響力期刊7篇)
1. Chuang MC, Lin SS, Ohniwa RL, Lee GH, Su YA, Chang YC, Tang MJ, Liu YW. Tks5 and Dynamin-2 enhance actin bundle rigidity in invadosomes to promote myoblast fusion. J. Cell Biol. 2019 Mar 20;218(5):1670-1685.
(Impact Factor:8.811)
[Mechanobiology & Skin Disease；本研究發現Tks5及Dynamin-2參與在侵襲體的形成及增加其硬度，侵襲體對於癌症轉移及肌肉發育與再生扮演重要的角色。未來可開發相關藥物抑制侵襲體的形成以抑制癌症轉移或增
加侵襲體的形成來幫助肌肉再生]
2. Lee CN, Hsu CK, Lee JY*. Recalcitrant extragenital giant condyloma acuminatum: A need for combination therapy. Dermatol Ther. 2019 Mar 5;32(3): e12867. (Impact Factor: 2.327)
[Mechanobiology & Skin Disease；利用局部抗病毒(podophyllotoxin)與免疫治療藥物(imiquimod)合併冷凍治療治癒一位難治的giant condyloma]
3. Guevara BEK, Hou PC, Huang HY, Chen WR, Wen YK, Chen WC, Lee JY, Hsu CK*. Late-onset comedonal Darier's disease caused by a recurrent ATP2A2 mutation. J Dermatol. 2019 Jan 21;46(6):E211-E212.
(Impact Factor: 3.072)
[EB & genetic diseases；報告一位台灣皮膚遺傳性疾病Darier’s disease患者的特殊臨床與病理表現]
4. Yeh YC, Lin HH, Tang MJ*. Dichotomy of the function of DDR1 in cells and disease progression. Biochim Biophys Acta Mol Cell Res. 2019 Apr 5; 1866(11):118473. (Impact Factor: 4.105)
[Fibrosis & Regenerative Medicine；膠原蛋白沉積是在癌組織和纖維化器官/病變中發現的常見特徵，本論文探討膠原蛋白受體DDR1在上皮細胞分化，細胞遷移，癌症進展和組織纖維化中的差異功能]
DOI:10.1016/j.bbamcr.2019.04.003
5. Hong YK, Lee YC, Cheng TL, Lai CH, Hsu CK, Kuo CH, Hsu YY, Jui-Ting Li, Chang BI, Ma CY, Lin SW, Wang KC, Shi GY, Wu HL*. Tumor Endothelial Marker 1 (TEM1/endosialin/CD248) Enhances Wound Healing
by Interacting with Platelet-Derived Growth Factor Receptors. J Invest Dermatol. 2019 Apr 12;139(10):2204-2214.e7. (Impact Factor: 7.143)
[Wound Healing & Plastic Surgery；研究中發現腫瘤內皮標誌一透過與血小板趨化生長因子接受器做用，而促進其下游的訊息傳遞，幫助傷口癒合，腫瘤內皮標誌一的表現可當傷口癒合重要的指標]
DOI:10.1016/j.jid.2019.03.1149
6. Onoufriadis A, Hsu CK, Eide CR, Nanda A, Orchard GE, Tomita K, Sheriff A, Scott W, Tierney C, Lee JYW, Gomaa NS, Desomchoke R, Lwin SM, Tu WT, Chen LY, Huang HY, Chao SC, Yu-Yun Lee J, Bare Y, Hayday T, Guy AL,
Liu L, Lees C, Hirdler T, Lovell P, Xia L, Dayrit JF, Calonje E, Simpson MA, Tolar J, Parsons M, McGrath JA. Exome sequencing identifies semi-dominant GPNMB mutations in amyloidosis cutis dyschromica.
J Invest Dermatol. 2019 Dec;139(12):2550-2554.e9. (Impact Factor: 7.143)
[EB & Genetic Diseases；國際合作探討GPNMB在皮膚遺傳性疾病Amyloidosis cutis dyschromica所扮演的角色]
7. Chang HH, Hsueh YS, Cheng YW, Ou HT, Wu MS. Association between Polymorphisms of OCT1and Metabolic Response to Metformin in Women with Polycystic Ovary Syndrome. Int. J. Mol. Sci. 2019; 20. pii: E1720
(Impact Factor: 4.183)
[Cancer & Others；此研究調查了OCT1和OCT2多態性與二甲雙胍在PCOS患者中的療效之間的關係]
8. Huang CW, Hsueh YY, Huang WC, Patel S, Li S*. Multipotent vascular stem cells contribute to neurovascular regeneration of peripheral nerve. Stem Cell Research & Therapy. 2019 Aug;10: Article number: 234.
(Impact Factor: 5.116)
[Fibrosis & Regenerative Medicine；在此文章中，我們成功自血管分離出具有多重分化能力的幹細胞，將其移植於周邊神經缺損的動物模式，證實此幹細胞可以直接分化為血管周圍細胞，並可維持神經與血管之間的
完整性，來達到促進神經再生的療效]
9. Plikus MV*, Chuong CM*. Understanding Skin Morphogenesis Across Developmental, Regenerative and Evolutionary levels. Exp Dermatol. 2019 Apr 5;28(4):327-331. (Impact Factor: 3.368)
[Fibrosis & Regenerative Medicine；形態發生的原理和驅動力是深入了解皮膚病因和機制的基礎，形態發生產生解剖學上精細且多樣功能的皮膚，以適應不斷變化的外部動態環境。]
10. Weber EL, Woolley TE, Yeh CY, Ou KL, Maini PK, Chuong CM*. Self-organizing hair peg-like structures from dissociated skin progenitor cells: New insights for human hair follicle organoid engineering and Turing patterning in
an asymmetric morphogenetic field. Exp Dermatol. 2019 Jan 25;28(4):355-366. (Impact Factor: 3.368)
[Hair Follicle & Skin Appendages；當人類皮膚細胞注入裸鼠皮膚，會形成新的毛囊，但效率很低。為了改良這種再生過程的研究，我們開發了一種體外系統，用以詳細分析形態發生細胞的行為，並調節參數以有效
觀察毛髮新生。]
11. Jiang TX, Harn HI, Ou KL, Lei M, Chuong CM*. Comparative regenerative biology of spiny (Acomys cahirinus) and laboratory (Mus musculus) mouse skin. Exp Dermatol. 2019 Feb 8; 28(4):442-449. (Impact Factor: 3.368)
[Fibrosis & Regenerative Medicine；皮膚切開後，非洲刺鼠能以無疤痕的方式修復全層皮膚傷口，使毛囊、皮脂腺和真皮完全再生。透過比較非洲刺鼠和鼠類的傷口癒合情況，可了解有關再生與修復的更多信息。]
12. Inaba M, Harn HI, Chuong CM*. Turing patterning with and without a global wave. PLoS Biology. 2019 March 25;17(3):e3000195. (Impact Factor: 7.076)
[Hair Follicle & Skin Appendages；週期性圖案化代表組織形態發生的基本過程。鳥類羽毛的形成從中線開始；然後形態發生波向兩側傳播，留下規則的六角形羽狀圖案。在不會飛的鳥中，羽毛會周期性地形成，但由
於缺乏全局波動，因此沒有精確的六角形圖案。]
DOI:10.1371/journal.pbio.3000195
13. Lin CH, Chiu PY, Hsueh YY, Shieh SJ, Wu CC, Wong TW, Chuong CM*, Hughes MW*. Regeneration of rete ridges in Lanyu pig (Sus scrofa): Insights for human skin wound healing. Exp Dermatol. 2019 Apr;28(4):472-479.
(Impact Factor: 2.868)
[Wound Healing & Plastic Surgery；我們開發了蘭嶼豬(Sus scrofa)全層傷口模型來探索組織再生，因為其結構和功能與人類相似，將有助於再生醫學領域知識。]
14. Widelitz RB, Lin GW, Lai YC, Mayer JA, Tang PC, Cheng HC, Jiang TX, Chen CF, Chuong CM. Morpho-regulation in diverse chicken feather formation: Integrating branching modules and sex hormone-dependent
morpho-regulatory modules. Dev Growth Differ. 61:124-138, 2019. (Impact Factor: 1.638)
[Hair Follicle & Skin Appendages；基本的羽毛分支形態發生可以透過性激素或其他環境因素調節，以改變形式、質地或顏色。性激素可以超越細胞集合體的遺傳特性，並指引羽毛形態，及影響蛻皮和羽毛循環。]
15. Solis MA*, Velásquez IM, Correa R and Huang LLH. Stem cells as a potential therapy for diabetes mellitus: a call-to- action in Latin America. Diabetology & Metabolic Syndrome. 2019 Mar 2;11:20. (Impact Factor: 2.361)
[Fibrosis & Regenerative Medicine；在此文章中，探討糖尿病及其相關治療需求，並說明幹細胞於治療上扮演重要角色]
16. Huang HP, Hsu CK, Lee JY*. A new superficial needle-scraping method for assessing Demodex density in papulopustular rosacea. J Cosmet Dermatol. 2019 Jul 25;19(4):896-900. (Impact Factor: 1.311)
[Mechanobiology & Skin Disease；用針頭定量酒渣患者的毛囊蟲數目]
17. Supsrisunjai C, Hsu CK, Michael M, Duval C, Lee JYW, Yang HS, Huang HY, Chaikul T, Onoufriadis A, Steiner RA, Ariëns RAS, Sarig O, Sprecher E, Schwartz-Eskin M, Samlaska C, Simpson MA, Calonje E, Parsons M,
McGrath JA*. Coagulation Factor XIII-A Subunit Missense Mutation in the Pathobiology of Autosomal Dominant Multiple Dermatofibromas. J Invest Dermatol. 2019 Sep;140(3):624-635.e7. (Impact Factor: 7.143)
[EB & Genetic Diseases；第一個找出家族性遺傳皮膚纖維瘤致病基因F13A1的皮膚遺傳研究]
18. Lee GH, Chang CL, Chiu WT, Hsiao TH, Chen PY, Wang KC, Kuo CH, Chen BH, Shi GY, Wu HL. A thrombomodulin-like gene is crucial to the collective migration of epibolic blastomeres during germ layer formation and
organogenesis in zebrafish. J. Biomed. Sci.Fu TF. 2019. (Impact Factor: 5.203)
[Fibrosis & Regenerative Medicine；本研究利用斑馬魚為研究模式發現凝血酶調節素在細胞膜上與肌動蛋白及微管相連結進而調控集體細胞移動，集體細胞移動對於胚胎發育，器官生長及癌細胞轉移扮演重要的角色]
19. Wu XS, Yeh CY, Harn HI, Jiang TX, Wu P, Widelitz RB, Baker RE, Chuong CM. Self-assembly of biological networks via adaptive patterning revealed by avian intradermal muscle network formation. Proc Natl Acad Sci U S A.
2019 May 28;116(22):10858-10867. (Impact Factor: 9.412)
[Hair Follicle & Skin Appendages；我們使用鳥類皮內肌肉網絡作為模型，揭示了肌肉網絡如何牢固地組裝，以適應外部干擾和刺激。]
20. Cheng AY, Lee CN, Hsieh FN, Lo TK, Huang HY, Hsu CK, Lee JYY, Yang CC*. “Spade sign” and inflammation/fibrosis limited to the upper and mid‐dermis as the pathognomonic features of acne keloidalis. J Dermatol 2019.
(Impact Factor: 3.072)
[Keloid；此文整理一種特殊的疤痕性掉髮dissecting folliculitis，其皮膚纖維化最後導致禿髮的過程值得探究。]
21. Yang HS, Yang CC, Hsu CK, Lee JYY, Chao SC, Tu WT. Exertional plantar blistering as an easily overlooked clue for epidermolysis bullosa simplex. Dermatol Sinica. 2019 Jul; 37:170-171. (Impact Factor: 0.808)
[EB & Genetic Diseases；本文報告一EB simplex病例 只有以腳底運動後起水泡來表現 提醒大家對此診斷的警覺度]
22. Solis MA, Huang LLH*. Hyaluronan induces a mitochondrial functional switch in fast-proliferating human mesenchymal stem cells. International Journal of Stem Cells. 12, 2019. Dec 31;13(1): 151-162. doi: 10.15283/ijsc19004
(Impact Factor: 1.870)
[Fibrosis & Regenerative Medicine；此文章說明再生醫學領域使用的透明質酸若少量應用於人類間葉幹細胞會誘導粒線體功能的調控，因而刺激幹細胞增生]
23. Chang WL, Wu H, Chiu YK, Wang S, Jiang TX, Luo ZL, Lin YC, Li A, Hsu JT, Huang HL, Gu HJ, Lin TY, Yang SM, Lee TT, Lai YC, Lei M, Shie MY, Yao CT, Chen YW, Tsai JC, Shieh SJ, Hwu YK, Cheng HC, Tang PC,
Hung SC, Chen CF, Habib M, Widelitz RB, Wu P, Juan WT, Chuong CM*. The Making of a Flight Feather: Bio-architectural Principles and Adaptation. Cell. (Impact Factor: 38.637)
[Hair Follicle & Skin Appendages；我們採用跨領域多學科的方法來研究不同功能的羽毛形式，解構其羽毛桿和葉片演化與分化之結構與分子控制機制。]
DOI:10.1016/j.cell.2019.11.008
2018年國際期刊論文(共14篇，IF 值＞6之高影響力期刊5篇)
1. Yang CC, Wong TW, Lee CH, Hong CH, Chang CH, Lai FJ, et al. Efficacy and safety of topical SR-T100 gel in treating actinic keratosis in Taiwan: A Phase III randomized double-blind vehicle-controlled parallel trial. J Dermatol Sci.
2018 Jun;90(3):295-302. (Impact Factor: 3.681)
[Mechanobiology & Skin Disease；此藥物SR-T100在此臨床試驗中不僅對日光性角化症的治療有效，還能促進皮膚彈性纖維再生，改善老化。]
2. Wu P, Yan J, Lai YC, Ng CS, Li A, Jiang X, Elsey RM, Widelitz R, Bajpai R, Li WH, Chuong CM. Multiple Regulatory Modules Are Required for Scale-to-Feather Conversion. Mol Biol Evol. 2018 Feb;35(2):417-30.
(Impact Factor: 11.062)
[Hair Follicle & Skin Appendages；本論文藉由研究羽毛和鱗片其生成的特性來推論器官新生的過程，發現其生成路徑包含幾個主要過程：生長區域形成，毛囊泡內陷，上皮分支，羽毛角質蛋白分化和真皮乳突形成。]
3. Su HJ, Cheng AY, Liu CH, Chu CB, Lee CN, Hsu CK, Lee JY, Yang CC. Primary scarring alopecia: A retrospective study of 89 patients in Taiwan. J Dermatol. 2018 Jan 16;45(4):450-455. (Impact Factor: 3.072)
[Hair Follicle & Skin Appendages；在此文章中，我們發現疤痕性禿髮(scarring alopecia)的種類及嚴重度與性別、年紀、不同發炎細胞等相關，可以提供未來研究頭皮fibrosis影響禿髮的方向與題材。]
4. Onoufriadis A, Hsu CK, Ainali C, Ung CY, Rashidghamat E, Yang HS, Huang HY, Niazi U, Tziotzios C, Yang JC, Nuamah R, Tang MJ, Saxena A, de Rinaldis E, McGrath JA. Time Series Integrative Analysis of RNA Sequencing and
MicroRNA Expression Data Reveals Key Biologic Wound Healing Pathways in Keloid-Prone Individuals. J Invest Dermatol. 2018 Dec;138(12):2690-2693. (Impact Factor: 7.143)
[Keloid；我們在蟹足腫的正常皮膚做兩次切片檢查，利用次世代基因定序RNAseq提供蟹足腫早期傷口癒合的轉錄體與microRNA資訊]
5. Hughes MW, Jiang TX, Plikus MV, Guerrero-Juarez CF, Lin CH, Schafer C, Maxson R, Widelitz RB, Chuong CM. Msx2 Supports Epidermal Competency during Wound-Induced Hair Follicle Neogenesis. J Invest Dermatol.
2018, Mar 23; 138(9):2041-2050. pii: S0022-202X(18)31736-6. (Impact Factor: 7.143)
[Hair Follicle & Skin Appendages；在傷口癒合過程中，毛囊間細胞再生需要上皮Msx2表現，經由支持間質誘導的上皮能力來調節WIHN傷口誘導的毛囊新生效率。]
6. Hsu CK, Lin HH, Harn HI, Ogawa R, Wang YK, Ho YT, Chen WR, Lee YC, Lee JY, Shieh SJ, Cheng CM, McGrath JA, Tang MJ. Caveolin-1 Controls Hyperresponsiveness to Mechanical Stimuli and Fibrogenesis-Associated
RUNX2 Activation in Keloid Fibroblasts. J Invest Dermatol. 2018 Jan;138(1):208-18. (Impact Factor: 7.143)
[Keloid；利用生物力學探討蟹足腫的作用機轉，除了找出RUNX2為重要的調控因子外，我們也發現Caveolin-1是調控蟹足腫纖維母細胞軟硬度的關鍵蛋白]
7. Hsu CK, Lin HH, Harn HI, Hughes MW, Tang MJ, Yang CC. Mechanical forces in skin disorders. J Dermatol Sci. 2018 Jan;90(3):232-40. (Impact Factor: 3.681)
[Mechanobiology & Skin Disease；此文章整理生物機械力在皮膚疾病所扮演的致病角色，包含表皮鬆解症、蟹足腫、禿髮及皮膚癌，以及機械力對皮膚再生的影響。]
DOI:10.1016/j.jdermsci.2018.03.004
8. Chen W, Song Z, Yang CC*, Hao F*. Symmetrical acral keratoderma revisited: proposal for a new term, 'pigmented carpotarsal hyperkeratosis'. J Eur Acad Dermatol Venereol. 2018 Oct 4; 33(2):277-280. (Impact Factor: 5.248)
[Mechanobiology & Skin Disease；此文章整理好發在亞洲人的肢端皮膚角化症的臨床病理特徵，此病以角化特徵為主，影響皮膚機械力的改變。]
9. Hsueh WT, Hung KS, Chen YC, Huang YT, Hsu CK, Ogawa R, Hsueh YY. Adjuvant Radiotherapy After Keloid Excision: Preliminary Experience in Taiwan. Ann Plast Surg. 2018. 82(1S Suppl 1):S39-S44 (Impact Factor: 1.354)
[Keloid；台灣第一個利用外科手術加上放射線治療蟹足腫的臨床文獻]
DOI:10.1097/SAP.0000000000001728
10. Lee CN, Chen W, Hsu CK, Weng TT, Lee JY, Yang CC. Dissecting folliculitis (dissecting cellulitis) of the scalp: a 66-patient case series and proposal of classification. J Dtsch Dermatol Ges. 2018 Aug 31;16(10):1219-1226.
(Impact Factor: 3.664)
[Hair follicle & skin appendages；此文整理一種特殊的疤痕性掉髮dissecting folliculitis，其皮膚纖維化最後導致禿髮的過程值得探究。]
11. Chan YH, Hsieh FN, Lin LY, Lee JY, Yang CC. Cutaneous Angiosarcoma- a report of 20 Taiwanese patients. Dermatol Sinica. 2018 Sep;36:143-145. (Impact Factor: 0.921)
[Cancer & Others；此文章整理頭部傷口常見原因之一，血管肉瘤的特徵及治療方法。]
12. Wei WC, Bianchi F, Wang YK, Tang MJ, Ye H, Glitsch MD. Coincidence detection of membrane stretch and extracellular pH by the proton-sensing receptor OGR1 (GPR68). Current Biol. 2018 Dec 3;28: 1-9. (Impact Factor: 9.601)
[Mechanobiology & Skin Disease OGR1（aka GPR68）需要細胞伸展和細胞外氫離子來激活，細胞伸展和細胞外氫離子協同促進OGR1信號傳導。細胞伸展誘導的肌動蛋白聚合對於OGR1活性至關重要，肌動蛋白解聚
限制OGR1在細胞伸展後之活性反應。]
13. Chen WC, Hung KS, Chen SH, Shieh SJ, Lee JW, Hsiao JR, Lee YC. Intensive Care Unit Versus Ward Management After Anterolateral Thigh Flap Reconstruction After Oral Cancer Ablation. Ann Plast Surg.
2018 Feb;80(2S Suppl 1):S11-S14. (Impact Factor: 1.354)
[Wound Healing & Plastic Surgery；對病房或ICU進行口腔癌消融後進行前大腿前皮瓣重建的患者的術後護理可產生相當的皮瓣結局。]
DOI:10.1097/SAP.0000000000001301
14. Chuang KL, Liang FW, Shieh SJ, Lu TH. The Incidence of Necrotizing Fasciitis in Taiwan: A Nationwide Population-Based Study. Ann Plast Surg. 2018 Feb;80(2S Suppl 1):S75-S78. (Impact Factor: 1.354)
[Wound Healing & Plastic Surgery；本論文利用Pearson相關係數（r）檢查中央氣象局在台灣各地區2005年至2010年記錄的月平均氣溫與壞死性筋膜炎病例之間的關係]
DOI:10.1097/SAP.0000000000001298
