Cheng-Ming Chuong MD PhD

Yue Z, Jiang TX, Wu P, Widelitz RB, Chuong CM. Sprouty / FGF signaling regulates the proximal-distal feather morphology and the size of dermal papillae. Developmental Biology 2012 Sep 18 online.

Ji Li, Ting-Xin Jiang, Michael W. Hughes, Ping Wu, Juehua Yu, Randall B. Widelitz, Guoping Fan and Cheng-Ming Chuong. Progressive Alopecia Reveals Decreasing Stem Cell Activation Probability during Aging of Mice with Epidermal Deletion of DNA Methyltransferase 1. Journal of Investigative Dermatology 2012 Sep 18 online

Chen Siang Ng, Ping Wu, John Foley, Anne Foley, Merry-Lynn McDonald, Wen-Tau Juan, Chih-Jen Huang, Yu-Ting Lai, Wen-Sui Lo, Chih-Feng Chen, Suzanne M. Leal, Huanmin Zhang, Randall B. Widelitz, Pragna I. Patel, Wen-Hsiung Li, and Cheng-Ming Chuong. The Chicken Frizzle Feather Is Due to an 帢-Keratin (KRT75) Mutation That Causes a Defective Rachis. PLoS Genetics. 2012, Jul 8(7) 1-16.

Chuong CM, Randall VA, Widelitz RB, Wu P, Jiang TX. Physiological regeneration of skin appendages and implications for regenerative medicine. Physiology (Bethesda). 2012 Apr;27(2):61-72. Review

Chen CC, Chuong CM. Multi-layered environmental regulation on the homeostasis of stem cells: the saga of hair growth and alopecia. J Dermatol Sci. 2012 Apr;66(1):3-11. Epub 2012 Feb 24. Review.

Ming-Jer Tang MD PhD

Cheng CM, Tang MJ. Review series - Mechanotransduction from physiology to disease states. J Cell Mol Med. 2013

Yeh YC, Wu CC, Wang YK, Tang MJ. DDR1 triggers epithelial cell differentiation by promoting cell adhesion through stabilization of E-cadherin. Mol Biol Cell. 2011

Yeh YC, Wei WC, Wang YK, Lin SC, Sung JM, Tang MJ. Transforming growth factor-{beta}1 induces Smad3-dependent {beta}1 integrin gene expression in epithelial-to-mesenchymal transition during chronic tubulointerstitial fibrosis. Am J Pathol. 2010

Lee PT, Lin HH, Jiang ST, Lu PJ, Chou KJ, Fang HC, Chiou YY, Tang MJ. Mouse kidney progenitor cells accelerate renal regeneration and prolong survival after ischemic injury. Stem Cells. 201

Wei WC, Lin HH, Shen MR, Tang MJ. Mechanosensing machinery for cells under low substratum rigidity. Am J Physiol Cell Physiol. 2008

Michael W. Hughes PhD

Michael W. Hughes, Ting-Xin Jiang, Sung-Jan Lin, Randall B. Widelitz, and Cheng Ming Chuong: DISRUPTED ECTODERMAL ORGAN MORPHOGENESIS IN MICE WITH A CONDITIONAL DELETION OF HISTONE DEACETYLASE 1, 2 IN THE EPIDERMIS. JID, Submitted July 2012, Accepted April 2013.

Shan-Chang Chueh, Sung-Jan Lin, Chih-Chiang Chen, Mingxing Lei, Ling Mei Wang, Randall, Widelitz, Michael W Hughes, Ting-Xing Jiang & Cheng Ming Chuong: THERAPEUTIC STRATEGY FOR HAIR REGENERATION: HAIR CYCLE ACTIVATION, NICHE ENVIRONMENT MODULATION, WOUND-INDUCED 5 FOLLICLE NEOGENESIS, AND STEM CELL ENGINEERING. Expert Opin. Biol. Ther, 2012.

Ji Li, Ting-Xin Jiang, Michael W. Hughes, Ping Wu, Randall B. Widelitz, Guoping Fan and Cheng-Ming Chuong: PROGRESSIVE ALOPECIA REVEALS DECREASING STEM CELL ACTIVATION PROBABILITY DURING AGING OF MICE WITH EPIDERMAL DELETION OF DNA METHYLTRANSFERASE. JID 2012.206.

Hughes M, Wu P, Jiang J, Lin S, Dong C, Li A, Hsieh F, Widelitz R, and Chuong C: IN SEARCH OF THE GOLDEN FLEECE: UNRAVELING PRINCIPLES OF MORPHOGENESIS BY STUDYING THE INTEGRATIVE BIOLOGY OF SKIN APPENDAGES. Integ Biol 3: 388-407, 2011.

Yeh J, Green L, Jiang T, Plikus M, Huang E, Chang R, Hughes M, Chuong C, and Tuan T: ACCELERATED CLOSURE OF SKIN WOUNDS IN MICE DEFICIENT IN THE HOMEOBOX GENE MSX2. Wound Rep Reg 17: 639��648, 2009.

Chia-Ching (Josh) Wu, PhD

Wu CC, Chen YC, Chang YC, Wang LW, Lin YC, Chiang YL, Ho CJ, Huang CC. Human umbilical vein endothelial cells protect against hypoxic-ischemic damage in neonatal brain via stromal cell-derived Factor 1/C-X-C chemokine receptor type 4. Stroke (2013) (Online Published)

Hsueh YY, Chiang YL, Wu CC, Lin SC. Spheroid formation and neural induction in human adipose-derived stem cells on a chitosan-coated surface. Cells Tissues Organs. (2012) 196(2):117-28.

Chen TJ, Wu CC, Tang MJ, Huang JS, Su FC, Complexity of the tensegrity model for dynamic energy and force distribution of cytoskeleton during cell spreading, PLOS One (2010) 5 (12), ppe14392.

Sung ML, Wu CC, Chang HI, Yen CK, Chen HJ, Cheng JC, Chien S, Chen CN. Shear stress inhibits homocysteine-induced stromal cell-derived factor-1 expression in endothelial cells, Circulation Research (2009) 105,pp755-763.

Wu CC, Li YS, Haga JH, Kaunas R, Chiu JJ, Su FC, Usami S, Chien S. Directional shear flow and Rho activation prevent the endothelial cell apoptosis induced by micropatterned anisotropic geometry, PNAS (2007) 104,pp 1254-9

Chao-Kai Hsu MD

Hsu CK, Lee JY, Tang MJ. Chapter: Pathogenesis of scar: an overview. Book:�cars and Scarring: Causes, Types and Treatment Options�� Nova Science Publishers.

Ogawa R, Hsu CK. Mechanobiological Dysregulation of the Epidermis and Dermis in Skin Disorders and in Degeneration. JCMM. Review.

Tseng SH, Hsu CK, Lee JY, Tzeng SY, Chen WR, Liaw YK. Noninvasive evaluation of collagen and hemoglobin contents and scattering property of in vivo keloid scars and normal skin using diffuse reflectance spectroscopy: pilot study. 2012 Jul;17(7):077005

Hsu CK, Hsu ML, Lee JY. Demodicosis: A clinical pathological study. J Am Acad Dermatol. 2009 Mar;60(3):453-62.

Hsu CK, Akiyama M, Nemoto-Hasebe I, Nomura T, Sandilands A, Chao SC, Lee JY, Sheu HM, McLean WH, Shimizu H. Analysis of Taiwanese ichthyosis vulgaris families further demonstrates differences in FLG mutations between European and Asian populations. Br J Dermatol. 2009 Aug;161(2):448-51

Chao-Chun Yang MD

Garza LA, Yang CC, Zhao T, Blatt HB, Lee M, He H, Stanton DC, Carrasco L, Spiegel JH, Tobias JW, Cotsarelis G. Bald scalp in men with androgenetic alopecia retains hair follicle stem cells but lacks CD200-rich and CD34-positive hair follicle progenitor cells. J Clin Invest 121:613-22, 2011.

Yang CC, Cotsarelis G. Review of hair follicle dermal cells. J Dermatol Sci. 57:2-11, 2010.

Chen YA, Hsu CK, Lee JYY, Yang CC*. Linear lupus panniculitis of the scalp presenting as alopecia along Blaschko's line: a distinct variant of lupus panniculitis in East Asians? J Dermatol 39:385-88, 2012.

Wu MC, Yang CC*, Tsai RY, Chen W. Late-onset alopecia areata: a retrospective study of 73 patients from Taiwan. J Eur Acad Dermatol Venereol 27:468-72, 2013.

Yang CC, Lee CT, Hsu CK, Lee YP, Wong TW, Chao SC, Lee JYY, Sheu HM, Chen W. An early intervention with high-dose steroid pulse therapy can prolong the disease-free interval of severe alopecia areata: experience of 85 patients in an open hospital-based retrospective study. Ann Dermatol (In press)

Wen-Tai Chiu PhD

Chou TC, Chiu HC, Kuo CJ, Wu CM, Syu WJ, Chiu WT, Chen CS. Enterohemorrhagic Escherichia coli O157:H7 Shiga-like toxin 1 is required for full pathogenicity and activation of the p38 MAPK pathway in Caenorhabditis elegans. Cell Microbiol. 2012 Sep 17.

Zhang N, Wei P, Gong A, Chiu WT, Lee HT, Colman H, Huang H, Xue J, Liu M, Wang Y, Sawaya R, Xie K, Yung WK, Medema RH, He X, Huang S. FoxM1 promotes 帣-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis. Cancer Cell. 2011 Oct 18;20(4):427-42.

Chen YF, Chiu WT, Chen YT, Lin PY, Huang HJ, Chou CY, Chang HC, Tang MJ, Shen MR. Calcium store sensor stromal-interaction molecule 1-dependent signaling plays an important role in cervical cancer growth, migration, and angiogenesis. Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15225-30.

Chiu WT, Lee HT, Huang FJ, Aldape KD, Yao J, Steeg PS, Chou CY, Lu Z, Xie K, Huang S. Caveolin-1 upregulation mediates suppression of primary breast tumor growth and brain metastases by stat3 inhibition. Cancer Res. 2011 Jul 15;71(14):4932-43.

Huang FJ, Steeg PS, Price JE, Chiu WT, Chou PC, Xie K, Sawaya R, Huang S. Molecular basis for the critical role of suppressor of cytokine signaling-1 in melanoma brain metastasis. Cancer Res. 2008 Dec 1;68(23):9634-42.

Cheng-Ming Chuong MD PhD

Yue Z, Jiang TX, Wu P, Widelitz RB, Chuong CM. Sprouty / FGF signaling regulates the proximal-distal feather morphology and the size of dermal papillae. Developmental Biology 2012 Sep 18 online.

Ji Li, Ting-Xin Jiang, Michael W. Hughes, Ping Wu, Juehua Yu, Randall B. Widelitz, Guoping Fan and Cheng-Ming Chuong. Progressive Alopecia Reveals Decreasing Stem Cell Activation Probability during Aging of Mice with Epidermal Deletion of DNA Methyltransferase 1. Journal of Investigative Dermatology 2012 Sep 18 online

Chen Siang Ng, Ping Wu, John Foley, Anne Foley, Merry-Lynn McDonald, Wen-Tau Juan, Chih-Jen Huang, Yu-Ting Lai, Wen-Sui Lo, Chih-Feng Chen, Suzanne M. Leal, Huanmin Zhang, Randall B. Widelitz, Pragna I. Patel, Wen-Hsiung Li, and Cheng-Ming Chuong. The Chicken Frizzle Feather Is Due to an 帢-Keratin (KRT75) Mutation That Causes a Defective Rachis. PLoS Genetics. 2012, Jul 8(7) 1-16.

Chuong CM, Randall VA, Widelitz RB, Wu P, Jiang TX. Physiological regeneration of skin appendages and implications for regenerative medicine. Physiology (Bethesda). 2012 Apr;27(2):61-72. Review

Chen CC, Chuong CM. Multi-layered environmental regulation on the homeostasis of stem cells: the saga of hair growth and alopecia. J Dermatol Sci. 2012 Apr;66(1):3-11. Epub 2012 Feb 24. Review.

Ming-Jer Tang MD PhD

Cheng CM, Tang MJ. Review series - Mechanotransduction from physiology to disease states. J Cell Mol Med. 2013

Yeh YC, Wu CC, Wang YK, Tang MJ. DDR1 triggers epithelial cell differentiation by promoting cell adhesion through stabilization of E-cadherin. Mol Biol Cell. 2011

Yeh YC, Wei WC, Wang YK, Lin SC, Sung JM, Tang MJ. Transforming growth factor-{beta}1 induces Smad3-dependent {beta}1 integrin gene expression in epithelial-to-mesenchymal transition during chronic tubulointerstitial fibrosis. Am J Pathol. 2010

Lee PT, Lin HH, Jiang ST, Lu PJ, Chou KJ, Fang HC, Chiou YY, Tang MJ. Mouse kidney progenitor cells accelerate renal regeneration and prolong survival after ischemic injury. Stem Cells. 201

Wei WC, Lin HH, Shen MR, Tang MJ. Mechanosensing machinery for cells under low substratum rigidity. Am J Physiol Cell Physiol. 2008

Michael W. Hughes PhD

Michael W. Hughes, Ting-Xin Jiang, Sung-Jan Lin, Randall B. Widelitz, and Cheng Ming Chuong: DISRUPTED ECTODERMAL ORGAN MORPHOGENESIS IN MICE WITH A CONDITIONAL DELETION OF HISTONE DEACETYLASE 1, 2 IN THE EPIDERMIS. JID, Submitted July 2012, Accepted April 2013.

Shan-Chang Chueh, Sung-Jan Lin, Chih-Chiang Chen, Mingxing Lei, Ling Mei Wang, Randall, Widelitz, Michael W Hughes, Ting-Xing Jiang & Cheng Ming Chuong: THERAPEUTIC STRATEGY FOR HAIR REGENERATION: HAIR CYCLE ACTIVATION, NICHE ENVIRONMENT MODULATION, WOUND-INDUCED 5 FOLLICLE NEOGENESIS, AND STEM CELL ENGINEERING. Expert Opin. Biol. Ther, 2012.

Ji Li, Ting-Xin Jiang, Michael W. Hughes, Ping Wu, Randall B. Widelitz, Guoping Fan and Cheng-Ming Chuong: PROGRESSIVE ALOPECIA REVEALS DECREASING STEM CELL ACTIVATION PROBABILITY DURING AGING OF MICE WITH EPIDERMAL DELETION OF DNA METHYLTRANSFERASE. JID 2012.206.

Hughes M, Wu P, Jiang J, Lin S, Dong C, Li A, Hsieh F, Widelitz R, and Chuong C: IN SEARCH OF THE GOLDEN FLEECE: UNRAVELING PRINCIPLES OF MORPHOGENESIS BY STUDYING THE INTEGRATIVE BIOLOGY OF SKIN APPENDAGES. Integ Biol 3: 388-407, 2011.

Yeh J, Green L, Jiang T, Plikus M, Huang E, Chang R, Hughes M, Chuong C, and Tuan T: ACCELERATED CLOSURE OF SKIN WOUNDS IN MICE DEFICIENT IN THE HOMEOBOX GENE MSX2. Wound Rep Reg 17: 639��648, 2009.

Chia-Ching (Josh) Wu, PhD

Wu CC, Chen YC, Chang YC, Wang LW, Lin YC, Chiang YL, Ho CJ, Huang CC. Human umbilical vein endothelial cells protect against hypoxic-ischemic damage in neonatal brain via stromal cell-derived Factor 1/C-X-C chemokine receptor type 4. Stroke (2013) (Online Published)

Hsueh YY, Chiang YL, Wu CC, Lin SC. Spheroid formation and neural induction in human adipose-derived stem cells on a chitosan-coated surface. Cells Tissues Organs. (2012) 196(2):117-28.

Chen TJ, Wu CC, Tang MJ, Huang JS, Su FC, Complexity of the tensegrity model for dynamic energy and force distribution of cytoskeleton during cell spreading, PLOS One (2010) 5 (12), ppe14392.

Sung ML, Wu CC, Chang HI, Yen CK, Chen HJ, Cheng JC, Chien S, Chen CN. Shear stress inhibits homocysteine-induced stromal cell-derived factor-1 expression in endothelial cells, Circulation Research (2009) 105,pp755-763.

Wu CC, Li YS, Haga JH, Kaunas R, Chiu JJ, Su FC, Usami S, Chien S. Directional shear flow and Rho activation prevent the endothelial cell apoptosis induced by micropatterned anisotropic geometry, PNAS (2007) 104,pp 1254-9

Chao-Kai Hsu MD

Hsu CK, Lee JY, Tang MJ. Chapter: Pathogenesis of scar: an overview. Book:�cars and Scarring: Causes, Types and Treatment Options�� Nova Science Publishers.

Ogawa R, Hsu CK. Mechanobiological Dysregulation of the Epidermis and Dermis in Skin Disorders and in Degeneration. JCMM. Review.

Tseng SH, Hsu CK, Lee JY, Tzeng SY, Chen WR, Liaw YK. Noninvasive evaluation of collagen and hemoglobin contents and scattering property of in vivo keloid scars and normal skin using diffuse reflectance spectroscopy: pilot study. 2012 Jul;17(7):077005

Hsu CK, Hsu ML, Lee JY. Demodicosis: A clinical pathological study. J Am Acad Dermatol. 2009 Mar;60(3):453-62.

Hsu CK, Akiyama M, Nemoto-Hasebe I, Nomura T, Sandilands A, Chao SC, Lee JY, Sheu HM, McLean WH, Shimizu H. Analysis of Taiwanese ichthyosis vulgaris families further demonstrates differences in FLG mutations between European and Asian populations. Br J Dermatol. 2009 Aug;161(2):448-51

Chao-Chun Yang MD

Garza LA, Yang CC, Zhao T, Blatt HB, Lee M, He H, Stanton DC, Carrasco L, Spiegel JH, Tobias JW, Cotsarelis G. Bald scalp in men with androgenetic alopecia retains hair follicle stem cells but lacks CD200-rich and CD34-positive hair follicle progenitor cells. J Clin Invest 121:613-22, 2011.

Yang CC, Cotsarelis G. Review of hair follicle dermal cells. J Dermatol Sci. 57:2-11, 2010.

Chen YA, Hsu CK, Lee JYY, Yang CC*. Linear lupus panniculitis of the scalp presenting as alopecia along Blaschko's line: a distinct variant of lupus panniculitis in East Asians? J Dermatol 39:385-88, 2012.

Wu MC, Yang CC*, Tsai RY, Chen W. Late-onset alopecia areata: a retrospective study of 73 patients from Taiwan. J Eur Acad Dermatol Venereol 27:468-72, 2013.

Yang CC, Lee CT, Hsu CK, Lee YP, Wong TW, Chao SC, Lee JYY, Sheu HM, Chen W. An early intervention with high-dose steroid pulse therapy can prolong the disease-free interval of severe alopecia areata: experience of 85 patients in an open hospital-based retrospective study. Ann Dermatol (In press)

Wen-Tai Chiu PhD

Chou TC, Chiu HC, Kuo CJ, Wu CM, Syu WJ, Chiu WT, Chen CS. Enterohemorrhagic Escherichia coli O157:H7 Shiga-like toxin 1 is required for full pathogenicity and activation of the p38 MAPK pathway in Caenorhabditis elegans. Cell Microbiol. 2012 Sep 17.

Zhang N, Wei P, Gong A, Chiu WT, Lee HT, Colman H, Huang H, Xue J, Liu M, Wang Y, Sawaya R, Xie K, Yung WK, Medema RH, He X, Huang S. FoxM1 promotes 帣-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis. Cancer Cell. 2011 Oct 18;20(4):427-42.

Chen YF, Chiu WT, Chen YT, Lin PY, Huang HJ, Chou CY, Chang HC, Tang MJ, Shen MR. Calcium store sensor stromal-interaction molecule 1-dependent signaling plays an important role in cervical cancer growth, migration, and angiogenesis. Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15225-30.

Chiu WT, Lee HT, Huang FJ, Aldape KD, Yao J, Steeg PS, Chou CY, Lu Z, Xie K, Huang S. Caveolin-1 upregulation mediates suppression of primary breast tumor growth and brain metastases by stat3 inhibition. Cancer Res. 2011 Jul 15;71(14):4932-43.

Huang FJ, Steeg PS, Price JE, Chiu WT, Chou PC, Xie K, Sawaya R, Huang S. Molecular basis for the critical role of suppressor of cytokine signaling-1 in melanoma brain metastasis. Cancer Res. 2008 Dec 1;68(23):9634-42.